Revista Biomédica Revisada Por Pares
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Palabras clave: Delirium, Antipsychotics, Atypical antipsychotics, Hospitalized patients, Epistemonikos, GRADE
Introduction
For the pharmacotherapy of delirium in elderly adults who are hospitalized, atypical antipsychotics are used. Currently, there is insufficient evidence on the effectiveness of this treatment in low complexity units.
Methods
We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE/PubMed, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis, and generated a summary of findings table using the GRADE approach.
Results and conclusions
We identified 13 systematic reviews that included three randomized trials. We concluded that the use of atypical antipsychotics in hospitalized patients likely increases the risk of mortality compared to placebo and could decrease the response rate associated with reducing the risk of adverse effects. Furthermore, using atypical antipsychotics probably results in low or no difference in the severity of delirium.
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Introduction
For the pharmacotherapy of delirium in elderly adults who are hospitalized, atypical antipsychotics are used. Currently, there is insufficient evidence on the effectiveness of this treatment in low complexity units.
Methods
We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE/PubMed, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis, and generated a summary of findings table using the GRADE approach.
Results and conclusions
We identified 13 systematic reviews that included three randomized trials. We concluded that the use of atypical antipsychotics in hospitalized patients likely increases the risk of mortality compared to placebo and could decrease the response rate associated with reducing the risk of adverse effects. Furthermore, using atypical antipsychotics probably results in low or no difference in the severity of delirium.
Autores:
Daniza Belén Bilicic Ubierna[1], Nicolás Cattarinich Schiffrin[1], Daniela Coronel Cárdenas[1], Rubén Soto Munizaga[2], José Miguel Bernucci Piedra[2]
Citación: Bilicic Ubierna DB, Cattarinich Schiffrin N, Coronel Cárdenas D, Soto Munizaga R, Bernucci Piedra JM. Atypical antipsychotics for delirium in hospitalized patients. Medwave 2021;21(04):e8168 doi: 10.5867/medwave.2021.04.8168
Fecha de envío: 27/11/2020
Fecha de aceptación: 22/3/2021
Fecha de publicación: 7/5/2021
Origen: No solicitado.
Tipo de revisión: Con revisión por pares externa, por dos árbitros a doble ciego.
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