Revista Biomédica Revisada Por Pares
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Palabras clave: Bronchiolitis, bronchodilator agents, adrenergic beta-2 receptor agonists, salbutamol, albuterol, children, Epistemonikos, GRADE.
Only Spanish version is available.
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INTRODUCCIÓN
La bronquiolitis es la inflamación aguda de las vías aéreas de pequeño calibre, teniendo como causa principal las infecciones virales. Es altamente frecuente en menores de dos años, sobretodo en menores de 12 meses. Existe gran controversia sobre el manejo de esta patología, siendo especialmente cuestionable el uso de beta-2 agonistas de corta acción tanto en el ámbito ambulatorio como hospitalario.
MÉTODOS
Para responder esta pregunta utilizamos Epistemonikos, la mayor base de datos de revisiones sistemáticas en salud a nivel mundial, la cual es mantenida mediante búsquedas en múltiples fuentes de información, incluyendo MEDLINE, EMBASE, Cochrane, entre otras. Extrajimos los datos desde las revisiones identificadas, reanalizamos los datos de los estudios primarios, realizamos un metanálisis, y preparamos una tabla de resumen de los resultados utilizando el método GRADE.
RESULTADOS Y CONCLUSIONES
Identificamos siete revisiones sistemáticas que en conjunto incluyen 47 estudios primarios, de los cuales 44 corresponden a ensayos aleatorizados. Concluimos que el uso de beta-2 agonistas podría no tener ningún beneficio en el manejo de la bronquiolitis, en términos de necesidad de hospitalización y/o duración de la misma. Por otra parte, podría aumentar efectos adversos como arritmias, sin embargo, la certeza de esta evidencia es baja
Autores:
Constanza Gómez[1,2], Gonzalo Alarcón[1,2], Lorena Cifuentes[1,2]
Citación: Gómez C, Alarcón G, Cifuentes L. Beta-2 agonists for the treatment of bronchiolitis. Medwave 2020;20(08):e7947 doi: 10.5867/medwave.2020.08.7947
Fecha de envío: 24/12/2018
Fecha de aceptación: 28/12/2018
Fecha de publicación: 3/9/2020
Origen: Este artículo es producto del Epistemonikos Evidence Synthesis Project de la Fundación Epistemonikos, en colaboración con Medwave para su publicación.
Tipo de revisión: Con revisión por pares sin ciego por parte del equipo metodológico del Centro Evidencia UC Synthesis Project
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