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Medwave 2017;17(7):e7018 doi: 10.5867/medwave.2017.07.7018
¿Es mejor la trabeculectomía modificada con dispositivo o la cirugía clásica para el manejo del glaucoma?
Is device-modified trabeculectomy better than classic surgery for treatment of glaucoma?
Eduardo Pimentel, Jimena Schmidt
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Abstract

Several techniques have emerged as complement or replacement for trabeculectomy, the standard surgery for glaucoma. Device-modified trabeculectomy is a recently developed technique whose results compared to the classical technique have not been fully defined. To answer this question, we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We identified eight systematic reviews including 34 studies overall. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. We concluded device-modified trabeculectomy probably leads to greater overall success rate and may decrease intraocular pressure more than classical surgery. In addition, this technique would probably have a better safety profile than standard trabeculectomy.


 
Problem

Glaucoma is the second leading cause of blindness worldwide according to the World Health Organization. Among the known risk factors for the development of this disease is the increase in intraocular pressure (IOP). Trabeculectomy is the standard surgery for patients with uncontrolled glaucoma despite medical treatment. The use of devices has been recently added to the classical surgical technique, in order t  promote the flow of aqueous humor from the anterior chamber and to avoid the post-trabeculectomy scaring by maintaining a continuous drainage of aqueous humor. In this line, the use of devices has been proposed as a technique that could improve surgical success and decrease the associated complication rate.

Methods

To answer the question, we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others, to identify systematic reviews and their included primary studies. We extracted data from the identified reviews and reanalyzed data from primary studies included in those reviews. With this information, we generated a structured summary using a pre-established format, which includes key messages, a summary of the body of evidence (presented as an evidence matrix in Epistemonikos), meta-analysis of the total of studies, a summary of findings table following the GRADE approach and a table of other considerations for decision-making. 

Key messages

  • Device-modified trabeculectomy probably leads to greater overall success and decrease in intraocular pressure than standard surgery.
  • Regarding to the safety of the technique, device-modified trabeculectomy probably decreases hypotonia and cataract surgery, and may decrease bleb leakage and narrow-chamber.
  • It is not clear whether the technique reduces reintervention and hyphema. 
About the body of evidence for this question

What is the evidence.
See evidence matrix  in Epistemonikos later

We found eight systematic reviews [1],[2],[3],[4],[5],[6],[7],[8]  that include 48 primary studies reported in 54 references [9],[10],[11],[12],[13],[14],[15],[16],[17],[18],
[19],[20],[21],[22],[23],[24],[25],[26],[27],[28],[29],[30],
[31],[32],[33],[34],[35],[36],[37],[38],[39],[40],[41],[42],
[43],[44],[45],[46],[47],[48],[49],[50],[51],[52],[53],[54], [55],[56],[57],[58],[59],[60],[61],[62]. Thirty four correspond to randomized controlled trials, reported in 40 references [9],[10],[12],[13],[14],[15],[16],[18],[19],[20],
[21],[22],[23],[25],[31],[32],[34],[36],[37],[38],[39],[42],
[43],[44],[45],[46],[47],[48],[49],[50],[52],[53],[54],[56],
[57],[58],[59],[60],[61],[62].This table and this summary are based on the latter.

What types of patients were included*

The characteristics of included patients were:

Regarding the type of glaucoma, 14 trials included patients with open angle glaucoma [12],[18],[19],[21],[25],[34],
[38],[42],[43],[49],[50],[54],[56],[59], two trials included patients with angle-closure glaucoma [48],[61] and 13  trials included more than one type of glaucoma [13],[14],
[15],[16],[32],[36],[37],[39],[45],[52],[57],[58],[60]. In five trials the type of glaucoma was not reported [10],[31],[44],[53],[62].

Regarding the severity of glaucoma, 21 trials included patients with glaucoma refractory to medical treatment. [13],[14],[15],[16],[18],[19],[21],[32],[36],[37],[38],[39],
[42],[43],[45],[49],[50],[52],[54],[56],[58] and one trial included patients with glaucoma refractory to surgical treatment [12]. In twelve trials the severity of glaucoma was not measured [10],[25],[31],[34],[44],[48],[53],[57],
[59],[60],[61],[62].

What types of interventions were included*

Regarding the type of intervention, 18 trials used amniotic membrane [12],[13],[14],[25],[31],[32],[34],[36],[37],
[48],[53],[54],[57],[58],[59],[60],[61],[62], nine trials used Ologen implants [16],[38],[39],[42],[44],[45],[49],[50],[52], five trials used ExPress mini glaucoma shunt [18],[19],[21],[43],[56], one trial used expanded polytetrafluoroethylene membrane implant (E-PTFE) [15], and one trial used absorbable gelatin film (Gelfilm) [10].

Regarding the use of mitomycin C (MMC), 15 trials did not use MMC in any of their arms [13],[14],[19],[21],[25],
[31],[32],[45],[48],[54],[57],[59],[60],[61],[62], 10 trials used MMC in both arms [10],[12],[15],[18],[36],[37],
[43],[53],[56],[58] and nine trials used MMC only in the control arms (trabeculectomy + MMC) [16],[34],[38],[39],[42],[44],[49],[50],[52].

All trials compared versus standard treatment (trabeculectomy).

What types of outcomes
were measured

The systematic reviews grouped the outcomes as follows: 

  • Post-operative intraocular pressure (IOP) in absolute numbers and percentage.
  • Drugs required during post-surgical care
  • Complete success (target IOP without associated medical treatment)
  • Qualified success (target IOP with associated medical treatment)
  • Adverse events (loss of visual acuity, hypotonia, re-intervention, hyphema, narrow chamber, bleb filtration, endophtalmitis, retinal detachment, corneal transplantation, need for cataract surgery, choroidal bleeding)
  • Improvement in visual acuity
  • Quality of life
  • Change in visual field
  • Cost/effectiveness

* The information about primary studies is extracted from the systematic reviews identified, unless otherwise specified.

[48],[53],[54],[57],[58],[59],[60],[61],[62]
Summary of findings

The information on the effects of device-modified trabeculectomy is based on 34 randomized trials including 1540 eyes.

Twenty-five trials measured absolute decrease in intraocular pressure (1164 eyes) [13],[14],[15],[16],[18],[21],[25],[31],[32],[34],[36],[37],[39],[42],[45],[48],[52],[53],[56],[57],[58],[59],[60],[61],[62], three trials assessed complete success (151 eyes) [18],[21],[56], six trials measured the need for reintervention (258 eyes) [18],[21],[39],[45],[49],[56], 14 trials measured hypotonia (695 eyes) [15],[18],[21],[34],[37],[42],[43],[45],[48],[49],[50],[52],[56],[62], 10 trials measured bleb filtration (521 eyes) [14],[16],[18],[21],[43],[48],[50],[52],[56],[62], 23 trials measured narrow chamber (1199 eyes) [14],[15],[18],[21],[25],[31],[32],[34],[36],[39],[42],[43],[48],[49],[50],[52],[56],[57],[58],[59],[60],[61],[62], 16 trials measured hyphema (818 eyes) [13],[14],[15],[16],[18],[21],[39],[43],[45],[49],[50],[52],[53],[56],[58],[60] and 3 trials measured the need for cataract surgery (264 eyes) [21],[43],[56].

The summary of findings is as follows:

  • Device-modified trabeculectomy may decrease intraocular pressure more than standard surgery. The certainty of the evidence is low
  • Device-modified trabeculectomy probably achieves greater complete success than standard surgery. The certainty of the evidence is moderate.
  • It is not clear whether device-modified trabeculectomy decreases reintervention, because the certainty of the evidence is very low.
  • Device-modified trabeculectomy probably decreases hypotonia. The certainty of the evidence is moderate.
  • Device-modified trabeculectomy may decrease bleb leakage. The certainty of the evidence is low.
  • Device-modified trabeculectomy may decrease narrow chamber. The certainty of the evidence is low.
  • It is not clear whether device-modified trabeculectomy reduces hyphema, because the certainty of the evidence is very low.
  • Device-modified trabeculectomy is likely to decrease cataract surgery. The certainty of the evidence is moderate.


Other considerations for decision-making

To whom this evidence does and does not apply
  • The evidence presented in this summary applies to patients with glaucoma, mainly those with open angle type and refractory to medical treatment.
  • Most of the patients included in the trials were adults, so the pediatric population may not be well represented. Because of this, the evidence is not yet conclusive as to recommend the use of this technique in this population.
About the outcomes included in this summary
  • The outcomes of decreasing intraocular pressure and achieving complete success were chosen because they are critical for surgery outcome. In addition, events such as reintervention and complications of surgery were selected as safety parameters. This selection is based on the opinion of the authors of the summary, but generally agree with the outcomes reported in the systematic reviews.
Balance between benefits and risks, and certainty of the evidence
  • This new technique probably achieves greater overall success, associated with a likely decrease in complications, and may also be superior in other outcomes. However, it is important to keep in mind the limitations of existing evidence.
  • The incidence of complications reported in the control group (trabeculectomy) differs from what has been reported in other studies, so the benefit would be lower in absolute terms. For example, some studies [68],[69],[70] report an incidence of hyphema of 69 per 1000, bleb leakage of 20 per 1000, hypotonia of 9 per 1000 and narrow chamber of 130 per 1000, related to trabeculectomy surgery.
Resource considerations
  • Although the use of devices in trabeculectomy increases the costs, it achieves greater complete success and fewer complications, so the cost/benefit would favor device-modified trabeculectomy. These results have been studied in developed countries and are consistent with this conclusion [8]. However, in settings where this option is being considered it is reasonable to carry out a formal economic analysis.
What would patients and their doctors think about this intervention
  • Faced with the evidence presented in this summary most clinicians should lean in favor of this technique.
  • However, in resource-constrained settings, the decision may vary. The limited certainty of existing evidence may also be a factor leading to variations in decision making.

Differences between this summary and other sources
  • Most systematic reviews reached conclusions similar to the ones presented here. However, the reviews are generally cautious with respect to these results because of the limitations of the primary studies and their risk of bias. Among the systematic reviews evaluated, it is important to highlight the review by Wang (2015) [7], because it evaluates 33 of the 34 randomized trials used in this analysis.
  • No clinical guidelines were found making a recommendation about these techniques.
Could this evidence change in the future?
  • The probability that future research changes the conclusions of this summary is high, particularly for outcomes where there is greater uncertainty.
  • There are at least three ongoing studies (two randomized trials [63],[64] and an observational study [65]) in the International Clinical Trials Registry Platform of the World Health Organization evaluating the use of device-modified trabeculectomy. In addition, there are at least two ongoing systematic reviews [66],[67] which could provide relevant information.
How we conducted this summary

Using automated and collaborative means, we compiled all the relevant evidence for the question of interest and we present it as a matrix of evidence.

Follow the link to access the interactive version: Device modified trabeculectomy in glaucoma

Notes

The upper portion of the matrix of evidence will display a warning of “new evidence” if new systematic reviews are published after the publication of this summary. Even though the project considers the periodical update of these summaries, users are invited to comment in Medwave or to contact the authors through email if they find new evidence and the summary should be updated earlier. After creating an account in Epistemonikos, users will be able to save the matrices and to receive automated notifications any time new evidence potentially relevant for the question appears.

The details about the methods used to produce these summaries are described here http://dx.doi.org/10.5867/medwave.2014.06.5997.

Epistemonikos foundation is a non-for-profit organization aiming to bring information closer to health decision-makers with technology. Its main development is Epistemonikos database (www.epistemonikos.org).

These summaries follow a rigorous process of internal peer review.

Conflicts of interest
The authors do not have relevant interests to declare.

Licencia Creative Commons Esta obra de Medwave está bajo una licencia Creative Commons Atribución-NoComercial 3.0 Unported. Esta licencia permite el uso, distribución y reproducción del artículo en cualquier medio, siempre y cuando se otorgue el crédito correspondiente al autor del artículo y al medio en que se publica, en este caso, Medwave.

 

Several techniques have emerged as complement or replacement for trabeculectomy, the standard surgery for glaucoma. Device-modified trabeculectomy is a recently developed technique whose results compared to the classical technique have not been fully defined. To answer this question, we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We identified eight systematic reviews including 34 studies overall. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. We concluded device-modified trabeculectomy probably leads to greater overall success rate and may decrease intraocular pressure more than classical surgery. In addition, this technique would probably have a better safety profile than standard trabeculectomy.

Autores: Eduardo Pimentel[1,2], Jimena Schmidt[2,3]

Filiación:
[1] Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
[2] Proyecto Epistemonikos, Santiago, Chile
[3] Departamento de Oftalmología, Facultad de Medicina, Pontificia Universidad Católica de Chile

E-mail: jimeschmidt@gmail.com

Correspondencia a:
[1] Facultad de Medicina
Pontificia Universidad Católica de Chile
Diagonal Paraguay 362
Santiago Centro
Chile.

Citación: Pimentel E, Schmidt J. Is device-modified trabeculectomy better than classic surgery for treatment of glaucoma?. Medwave 2017;17(7):e7018 doi: 10.5867/medwave.2017.07.7018

Fecha de envío: 7/7/2017

Fecha de aceptación: 1/8/2017

Fecha de publicación: 31/8/2017

Ficha PubMed

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Zhang Y, Cui W. Clinical efficacy of trabeculectomy combined with sub-flap implantation with amniotic membrane preserved in glycerin for angle closure glaucoma. Inner Mongolia Medical Journal. 2009; 41(3):473–476 | Link |

Zheng K, Huang Z, Zou H, Li H, Huang Y, Xie M. The comparison study of glaucoma trabeculectomy applying amniotic membrane or mitomycin C. Yan Ke Xue Bao [Eye science]. 2005; 21(2):84–87 | Link |

Prospective Randomized Study Comparing Ex-PRESS to Trabeculectomy. NCT01263561 | Link |

Comparison between ExPress shunt surgery and trabeculectomy for refractory glaucoma. JPRN-UMIN000008391 | Link |

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Xiaofei Tang, Jinjin Ji, Yan Zhang, Bing Tan, Yong Yang. Comparison of amniotic membrane transplantation and Mitomycin C in surgical treatment for glaucoma: a meta-analysis. PROSPERO 2017:CRD42017058746 | Link |

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Song BJ, Ramanathan M, Morales E, Law SK, Giaconi JA, Coleman AL, et al. Trabeculectomy and Combined Phacoemulsification-Trabeculectomy: Outcomes and Risk Factors for Failure in Primary Angle Closure Glaucoma. J Glaucoma. 2016 Sep;25(9):763-9 | CrossRef | PubMed |

Jampel HD, Musch DC, Gillespie BW, Lichter PR, Wright MM, Guire KE; Collaborative Initial Glaucoma Treatment Study Group. Perioperative complications of trabeculectomy in the collaborative initial glaucoma treatment study (CIGTS). Am J Ophthalmol. 2005 Jul;140(1):16-22 | PubMed |

Gedde SJ, Herndon LW, Brandt JD, Budenz DL, Feuer WJ, Schiffman JC. Surgical complications in the Tube Versus Trabeculectomy Study during the first year of follow-up. Am J Ophthalmol. 2007 Jan;143(1):23-31 | PubMed |

Edición Julio 2022
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