Diagnostic and therapeutic procedures that require the infusion of iodine containing contrast solutions are associated with the risk of contrast-induced nephropathy, a condition that can cause significant morbidity. Acetylcysteine has been proposed as a measure to prevent this condition. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified 20 systematic reviews including 64 randomized trials. We combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We concluded that even though acetylcysteine might not cause important adverse effects, it does not decrease need for dialysis, mortality or other important outcomes.

Autores: Ariel Izcovich[1,2], Gabriel Rada[3,4,5,6,7]

Filiación:
[1] Servicio de Clínica Médica, Hospital Alemán, Buenos Aires, Argentina
[2] Programa de Medicina Basada en Pruebas, Hospital Alemán, Buenos Aires, Argentina
[3] Programa de Salud Basada en Evidencia, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
[4] Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
[5] GRADE working group
[6] The Cochrane Collaboration
[7] Fundación Epistemonikos, Santiago, Chile

E-mail: radagabriel@epistemonikos.org

Correspondencia a:
[1] Facultad de Medicina
Pontificia Universidad Católica de Chile
Lira 63
Santiago Centro
Chile

Citación: Izcovich A, Rada G. Should acetylcysteine be used to prevent contrast induced nephropathy?. Medwave 2015 Abr;15(3):e6122 doi: 10.5867/medwave.2015.03.6122

Fecha de publicación: 15/4/2015

Ficha PubMed

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James MT, Ghali WA, Tonelli M, Faris P, Knudtson ML, Pannu N, et al. Acute kidney injury following coronary angiography is associated with a long-term decline in kidney function. Kidney Int. 2010 Oct;78(8):803-9. | CrossRef | PubMed |

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