Medwave 2021;21(6):e8223 doi: 10.5867/medwave.2021.06.8223
Rehabilitación pulmonar en COVID-19: protocolo de una revisión sistemática viva
Pulmonary rehabilitation for COVID-19: A living systematic review protocol
Stefanie Arce Pardo, Shuheng Lai, Luis Ortiz-Muñoz, Rocío Bravo-Jeria, Francisca Verdugo-Paiva, Gabriel Rada
Palabras clave: COVID-19, systematic review, respiratory muscle training, breathing exercises, pulmonary rehabilitation
Resumen
Objetivo
Proporcionar un resumen oportuno, riguroso y continuamente actualizado de la evidencia disponible sobre el papel de la rehabilitación pulmonar en el tratamiento de los pacientes con COVID-19.
Diseño
Es el protocolo de una revisión sistemática viva.
Fuente de datos
Realizaremos búsquedas en la plataforma L·OVE (Living OVerview of Evidence) para COVID-19, un sistema que mapea los componentes de las preguntas de investigación (PICO) en un repositorio mantenido a través de búsquedas regulares en bases de datos electrónicas, servidores de pre-impresión, registros de ensayos y otros recursos relevantes para COVID-19. No se aplicarán restricciones de fecha ni de idioma.
Criterios de elegibilidad para la selección de estudios y métodos
Se adaptó un protocolo común ya publicado para revisiones sistemáticas paralelas múltiples a las especificidades de la pregunta. Se incluirán ensayos aleatorios que evalúen el efecto de la rehabilitación pulmonar como monoterapia o en combinación con otras intervenciones frente a un tratamiento simulado o ningún tratamiento en pacientes con COVID-19. Dos revisores examinarán de forma independiente cada estudio para determinar su elegibilidad, extraerán los datos y evaluarán el riesgo de sesgo. Se agruparán los resultados mediante un metaanálisis y se aplicará el sistema Grading of Recommendations Assessment, Development and Evaluation (GRADE) para evaluar la certeza de las pruebas para cada resultado.
Ética y difusión
No se considera necesaria la aprobación ética. Los resultados de esta revisión se difundirán ampliamente a través de publicaciones revisadas por pares, redes sociales y medios de comunicación tradicionales.
The authors will not send a Spanish version of the manuscript.
Objective
This living systematic review aims to provide a timely, rigorous and continuously updated summary of the evidence available on the role of pulmonary rehabilitation in the treatment of patients with COVID-19.
Design
This is the protocol of a living systematic review.
Data sources
We will conduct searches in the L·OVE (Living OVerview of Evidence) platform for COVID-19, a system that maps PICO questions to a repository maintained through regular searches in electronic databases, preprint servers, trial registries and other resources relevant to COVID-19. No date or language restrictions will be applied.
Eligibility criteria for selecting studies and methods
We adapted an already published common protocol for multiple parallel systematic reviews to the specificities of this question. We will include randomized trials evaluating the effect of pulmonary rehabilitation as monotherapy or in combination with other interventions-versus sham or no treatment in patients with COVID-19. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. We will pool the results using meta-analysis and will apply the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to assess the certainty of the evidence for each outcome.
Ethics and dissemination
No ethics approval is considered necessary. The results of this review will be widely disseminated via peer-reviewed publications, social networks and traditional media.
Autores:
Stefanie Arce Pardo
[1], Shuheng Lai
[2], Luis Ortiz-Muñoz
[3,4], Rocío Bravo-Jeria
[5], Francisca Verdugo-Paiva
[3,6], Gabriel Rada
[3,6,7], COVID-19 L·OVE Working Group
Colaboradores:
Filiación:
[1] Dr. Exequiel González Cortés Hospital, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
[2] Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
[3] UC Evidence Center, Cochrane Chile Associated Center, Pontificia Universidad Católica de Chile, Santiago, Chile
[4] Chilean satellite of The Cochrane Effective Practice and Organisation of Care (EPOC), Santiago, Chile
[5] Departamento de Evaluación de Tecnologías Sanitarias y Salud Basada en Evidencia, División de Planificación Sanitaria, Ministerio de Salud, Santiago, Chile
[6] Epistemonikos Foundation, Santiago, Chile
[7] Internal Medicine Department, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
E-mail: leortizmunoz@uc.cl
Correspondencia a:
[1] Diagonal Paraguay 476,
Santiago, Chile
Citación:
Arce Pardo S, Lai S, Ortiz-Muñoz L, Bravo-Jeria R, Verdugo-Paiva F, Rada G.
Pulmonary rehabilitation for COVID-19: A living systematic review protocol . Medwave 2021;21(6):e8223 doi: 10.5867/medwave.2021.06.8223
Fecha de envío: 16/2/2021
Fecha de aceptación: 11/5/2021
Fecha de publicación: 7/7/2021
Origen: No solicitado
Tipo de revisión: Con revisión por pares externa, por cuatro árbitros a doble ciego
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- World Health Organization. Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. World Health Organization; 2020. [On line] | Link |
- Li LQ, Huang T, Wang YQ, Wang ZP, Liang Y, Huang TB, et al. COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol. 2020 Jun;92(6):577-583. | CrossRef | PubMed |
- World Health Organization. [On line] | Link |
- World Health Organization. WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. [On line] | Link |
- Hui DS, I Azhar E, Madani TA, Ntoumi F, Kock R, Dar O, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020 Feb;91:264-266. | CrossRef | PubMed |
- Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020 May;109:102433. | CrossRef | PubMed |
- Fang Z, Yi F, Wu K, Lai K, Sun X, Zhong N, et al. Clinical characteristics of Coronavirus Disease 2019 (COVID-9): An updated systematic review. BMJ (2020). | CrossRef |
- Nasiri M. COVID-19 clinical charaterisitics, and sex-specific rosk of mortality: systematic review and meta-analysis. BMJ (2020). | CrossRef |
- Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP, et al. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020 Mar-Apr;34:101623. | CrossRef | PubMed |
- Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Apr 30;382(18):1708-1720. | CrossRef | PubMed |
- Bai C, Chotirmall SH, Rello J, Alba GA, Ginns LC, Krishnan JA, et al. Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020). Eur Respir Rev. 2020 Oct 5;29(157):200287. | CrossRef | PubMed |
- Garrigues E, Janvier P, Kherabi Y, Le Bot A, Hamon A, Gouze H, et al. Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19. J Infect. 2020 Dec;81(6):e4-e6. | CrossRef | PubMed |
- Weerahandi H, Hochman KA, Simon E, Blaum C, Chodosh J, Duan E, et al. Post-discharge health status and symptoms in patients with severe COVID-19. medRxiv [Preprint]. 2020 Aug 14:2020.08.11.20172742. | CrossRef | PubMed |
- Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, Rochester C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013 Oct 15;188(8):e13-64. | CrossRef | PubMed |
- Nikoletou D, Man WD, Mustfa N, Moore J, Rafferty G, Grant RL, et al. Evaluation of the effectiveness of a home-based inspiratory muscle training programme in patients with chronic obstructive pulmonary disease using multiple inspiratory muscle tests. Disabil Rehabil. 2016;38(3):250-9. | CrossRef | PubMed |
- Pinheiro G, Saldías F. Entrenamiento muscular inspiratorio en el paciente con enfermedad pulmonar obstructiva crónica. Rev Chil Enf Respir 2011; 27: 116-123. | CrossRef |
- Hilton N, Solis-Moya A. Respiratory muscle training for cystic fibrosis. Cochrane Database Syst Rev. 2018 May 24;5(5):CD006112. | CrossRef | PubMed |
- Lau HM, Ng GY, Jones AY, Lee EW, Siu EH, Hui DS. A randomised controlled trial of the effectiveness of an exercise training program in patients recovering from severe acute respiratory syndrome. Aust J Physiother. 2005;51(4):213-9. | CrossRef | PubMed |
- COVID-19 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. National Institutes of Health. | Link |
- Zhao HM, Xie YX, Wang C. Recommendations for respiratory rehabilitation in adults with coronavirus disease 2019. Chin Med J (Engl). 2020 Jul;133(13):1595-1602. | CrossRef | PubMed |
- Wang TJ, Chau B, Lui M, Lam GT, Lin N, Humbert S. Physical Medicine and Rehabilitation and Pulmonary Rehabilitation for COVID-19. Am J Phys Med Rehabil. 2020 Sep;99(9):769-774. | CrossRef | PubMed |
- Candan SA, Elibol N, Abdullahi A. Consideration of prevention and management of long-term consequences of post-acute respiratory distress syndrome in patients with COVID-19. Physiother Theory Pract. 2020 Jun;36(6):663-668. | CrossRef | PubMed |
- Bissett B, Gosselink R, van Haren FMP. Respiratory Muscle Rehabilitation in Patients with Prolonged Mechanical Ventilation: A Targeted Approach. Crit Care. 2020 Mar 24;24(1):103. | CrossRef | PubMed |
- Elkins M, Dentice R. Inspiratory muscle training facilitates weaning from mechanical ventilation among patients in the intensive care unit: a systematic review. J Physiother. 2015 Jul;61(3):125-34. | CrossRef | PubMed |
- Qi D, Yan X, Xiang J, Peng J. Effects of early physical and pulmonary rehabilitation for severely and critically ill COVID-19 patients: a retrospective, cohort, and multicenter study. Research square 2020. | CrossRef |
- Spruit MA, Holland AE, Singh SJ, Tonia T, Wilson KC, Troosters T. COVID-19: Interim Guidance on Rehabilitation in the Hospital and Post-Hospital Phase from a European Respiratory Society and American Thoracic Society-coordinated International Task Force. Eur Respir J. 2020 Aug 13;56(6):2002197. | CrossRef | PubMed |
- Kalirathinam D, Guruchandran R, Subramani P. Comprehensive physiotherapy management in COVID-19: a narrative review. Scientia Medica Porto Alegre 2020; 30: e38030. | CrossRef |
- Battaglini D, Robba C, Caiffa S, Ball L, Brunetti I, Loconte M, et al. Chest physiotherapy: An important adjuvant in critically ill mechanically ventilated patients with COVID-19. Respir Physiol Neurobiol. 2020 Nov;282:103529. | CrossRef | PubMed |
- Simpson R, Robinson L. Rehabilitation After Critical Illness in People With COVID-19 Infection. Am J Phys Med Rehabil. 2020 Jun;99(6):470-474. | CrossRef | PubMed |
- Zhu C, Wu Y, Liu H, Ban Y, Ma X, Zhang Z. Early pulmonary rehabilitation for SARS-CoV-2 pneumonia: Experience from an intensive care unit outside of the Hubei province in China. Heart Lung. 2020 Sep-Oct;49(5):449-450. | CrossRef | PubMed |
- Thomas P, Baldwin C, Bissett B, Boden I, Gosselink R, Granger CL, et al. Physiotherapy management for COVID-19 in the acute hospital setting: clinical practice recommendations. J Physiother. 2020 Apr;66(2):73-82. | CrossRef | PubMed |
- Yang LL, Yang T. Pulmonary rehabilitation for patients with coronavirus disease 2019 (COVID-19). Chronic Dis Transl Med. 2020 May 14;6(2):79-86. | CrossRef | PubMed |
- Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015 Jan 1;4(1):1. | CrossRef | PubMed |
- Rada G, Verdugo-Paiva F, Ávila C, Morel Marambio M, Bravo-Jeria R, Pesce F, et al. Evidence synthesis relevant to COVID-19: a protocol for multiple systematic reviews and overviews of systematic reviews. Medwave. 2020 Apr 1;20(3):e7868. English, Spanish. | CrossRef | PubMed |
- Github repository [Internet] [Accessed 2020 July 14th. | Link |
- Methods for the special L·OVE of COVID-19. Santiago: Epistemonikos Foundation [On line] | Link |
- Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019 Aug 28;366:l4898. | CrossRef | PubMed |
- Guyatt GH, Oxman AD, Santesso N, Helfand M, Vist G, Kunz R, et al. GRADE guidelines: 12. Preparing summary of findings tables-binary outcomes. J Clin Epidemiol. 2013 Feb;66(2):158-72. | CrossRef | PubMed |
- Guyatt GH, Thorlund K, Oxman AD, Walter SD, Patrick D, Furukawa TA, et al. GRADE guidelines: 13. Preparing summary of findings tables and evidence profiles-continuous outcomes. J Clin Epidemiol. 2013 Feb;66(2):173-83. | CrossRef | PubMed |
- Review Manager (RevMan) [Software]. Version 5.3.5 Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
- Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008 Apr 26;336(7650):924-6. | CrossRef | PubMed |

World Health Organization. Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. World Health Organization; 2020. [On line] |
Link |

Li LQ, Huang T, Wang YQ, Wang ZP, Liang Y, Huang TB, et al. COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol. 2020 Jun;92(6):577-583. |
CrossRef |
PubMed |

World Health Organization. [On line] |
Link |

World Health Organization. WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. [On line] |
Link |

Hui DS, I Azhar E, Madani TA, Ntoumi F, Kock R, Dar O, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020 Feb;91:264-266. |
CrossRef |
PubMed |

Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020 May;109:102433. |
CrossRef |
PubMed |

Fang Z, Yi F, Wu K, Lai K, Sun X, Zhong N, et al. Clinical characteristics of Coronavirus Disease 2019 (COVID-9): An updated systematic review. BMJ (2020). |
CrossRef |

Nasiri M. COVID-19 clinical charaterisitics, and sex-specific rosk of mortality: systematic review and meta-analysis. BMJ (2020). |
CrossRef |

Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP, et al. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020 Mar-Apr;34:101623. |
CrossRef |
PubMed |

Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Apr 30;382(18):1708-1720. |
CrossRef |
PubMed |

Bai C, Chotirmall SH, Rello J, Alba GA, Ginns LC, Krishnan JA, et al. Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020). Eur Respir Rev. 2020 Oct 5;29(157):200287. |
CrossRef |
PubMed |

Garrigues E, Janvier P, Kherabi Y, Le Bot A, Hamon A, Gouze H, et al. Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19. J Infect. 2020 Dec;81(6):e4-e6. |
CrossRef |
PubMed |

Weerahandi H, Hochman KA, Simon E, Blaum C, Chodosh J, Duan E, et al. Post-discharge health status and symptoms in patients with severe COVID-19. medRxiv [Preprint]. 2020 Aug 14:2020.08.11.20172742. |
CrossRef |
PubMed |

Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, Rochester C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013 Oct 15;188(8):e13-64. |
CrossRef |
PubMed |

Nikoletou D, Man WD, Mustfa N, Moore J, Rafferty G, Grant RL, et al. Evaluation of the effectiveness of a home-based inspiratory muscle training programme in patients with chronic obstructive pulmonary disease using multiple inspiratory muscle tests. Disabil Rehabil. 2016;38(3):250-9. |
CrossRef |
PubMed |

Pinheiro G, Saldías F. Entrenamiento muscular inspiratorio en el paciente con enfermedad pulmonar obstructiva crónica. Rev Chil Enf Respir 2011; 27: 116-123. |
CrossRef |

Hilton N, Solis-Moya A. Respiratory muscle training for cystic fibrosis. Cochrane Database Syst Rev. 2018 May 24;5(5):CD006112. |
CrossRef |
PubMed |

Lau HM, Ng GY, Jones AY, Lee EW, Siu EH, Hui DS. A randomised controlled trial of the effectiveness of an exercise training program in patients recovering from severe acute respiratory syndrome. Aust J Physiother. 2005;51(4):213-9. |
CrossRef |
PubMed |

COVID-19 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. National Institutes of Health. |
Link |

Zhao HM, Xie YX, Wang C. Recommendations for respiratory rehabilitation in adults with coronavirus disease 2019. Chin Med J (Engl). 2020 Jul;133(13):1595-1602. |
CrossRef |
PubMed |

Wang TJ, Chau B, Lui M, Lam GT, Lin N, Humbert S. Physical Medicine and Rehabilitation and Pulmonary Rehabilitation for COVID-19. Am J Phys Med Rehabil. 2020 Sep;99(9):769-774. |
CrossRef |
PubMed |

Candan SA, Elibol N, Abdullahi A. Consideration of prevention and management of long-term consequences of post-acute respiratory distress syndrome in patients with COVID-19. Physiother Theory Pract. 2020 Jun;36(6):663-668. |
CrossRef |
PubMed |

Bissett B, Gosselink R, van Haren FMP. Respiratory Muscle Rehabilitation in Patients with Prolonged Mechanical Ventilation: A Targeted Approach. Crit Care. 2020 Mar 24;24(1):103. |
CrossRef |
PubMed |

Elkins M, Dentice R. Inspiratory muscle training facilitates weaning from mechanical ventilation among patients in the intensive care unit: a systematic review. J Physiother. 2015 Jul;61(3):125-34. |
CrossRef |
PubMed |

Qi D, Yan X, Xiang J, Peng J. Effects of early physical and pulmonary rehabilitation for severely and critically ill COVID-19 patients: a retrospective, cohort, and multicenter study. Research square 2020. |
CrossRef |

Spruit MA, Holland AE, Singh SJ, Tonia T, Wilson KC, Troosters T. COVID-19: Interim Guidance on Rehabilitation in the Hospital and Post-Hospital Phase from a European Respiratory Society and American Thoracic Society-coordinated International Task Force. Eur Respir J. 2020 Aug 13;56(6):2002197. |
CrossRef |
PubMed |

Kalirathinam D, Guruchandran R, Subramani P. Comprehensive physiotherapy management in COVID-19: a narrative review. Scientia Medica Porto Alegre 2020; 30: e38030. |
CrossRef |

Battaglini D, Robba C, Caiffa S, Ball L, Brunetti I, Loconte M, et al. Chest physiotherapy: An important adjuvant in critically ill mechanically ventilated patients with COVID-19. Respir Physiol Neurobiol. 2020 Nov;282:103529. |
CrossRef |
PubMed |

Simpson R, Robinson L. Rehabilitation After Critical Illness in People With COVID-19 Infection. Am J Phys Med Rehabil. 2020 Jun;99(6):470-474. |
CrossRef |
PubMed |

Zhu C, Wu Y, Liu H, Ban Y, Ma X, Zhang Z. Early pulmonary rehabilitation for SARS-CoV-2 pneumonia: Experience from an intensive care unit outside of the Hubei province in China. Heart Lung. 2020 Sep-Oct;49(5):449-450. |
CrossRef |
PubMed |

Thomas P, Baldwin C, Bissett B, Boden I, Gosselink R, Granger CL, et al. Physiotherapy management for COVID-19 in the acute hospital setting: clinical practice recommendations. J Physiother. 2020 Apr;66(2):73-82. |
CrossRef |
PubMed |

Yang LL, Yang T. Pulmonary rehabilitation for patients with coronavirus disease 2019 (COVID-19). Chronic Dis Transl Med. 2020 May 14;6(2):79-86. |
CrossRef |
PubMed |

Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015 Jan 1;4(1):1. |
CrossRef |
PubMed |

Rada G, Verdugo-Paiva F, Ávila C, Morel Marambio M, Bravo-Jeria R, Pesce F, et al. Evidence synthesis relevant to COVID-19: a protocol for multiple systematic reviews and overviews of systematic reviews. Medwave. 2020 Apr 1;20(3):e7868. English, Spanish. |
CrossRef |
PubMed |

Github repository [Internet] [Accessed 2020 July 14th. |
Link |

Methods for the special L·OVE of COVID-19. Santiago: Epistemonikos Foundation [On line] |
Link |

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019 Aug 28;366:l4898. |
CrossRef |
PubMed |

Guyatt GH, Oxman AD, Santesso N, Helfand M, Vist G, Kunz R, et al. GRADE guidelines: 12. Preparing summary of findings tables-binary outcomes. J Clin Epidemiol. 2013 Feb;66(2):158-72. |
CrossRef |
PubMed |

Guyatt GH, Thorlund K, Oxman AD, Walter SD, Patrick D, Furukawa TA, et al. GRADE guidelines: 13. Preparing summary of findings tables and evidence profiles-continuous outcomes. J Clin Epidemiol. 2013 Feb;66(2):173-83. |
CrossRef |
PubMed |

Review Manager (RevMan) [Software]. Version 5.3.5 Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.

Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008 Apr 26;336(7650):924-6. |
CrossRef |
PubMed |