Revista Biomédica Revisada Por Pares
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Palabras clave: mouth neoplasms, biomarkers, saliva, diagnosis, sensitivity, specificity
Introduction
Oral cancer has a 5-year survival rate of 50% because diagnosis is commonly performed at an advanced stage of the disease, so new diagnostic tools are needed. Nowadays, there is a vast number of publications suggesting the use of salivary biomarkers for oral cancer and potentially malignant disorders diagnosis, but their diagnostic accuracy is unclear. Thus, the goal of this systematic review is to evaluate the diagnostic accuracy of salivary biomarkers for oral cancer and potentially malignant disorders.
Methods
This protocol is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P). We will include primary studies assessing the diagnostic accuracy of salivary biomarkers for oral cancer and potentially malignant disorders. Studies must report data about sensitivity and specificity; gold standard must be the histopathology diagnosis. We will search MEDLINE, EMBASE, the Cochrane Library, and gray literature. Two authors will independently select the studies and extract the data. The methodology quality of studies will be determined using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2).
Expected results and conclusion
Our findings will provide information about the diagnostic accuracy of salivary biomarkers for oral cancer and potentially malignant disorders.
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Introduction
Oral cancer has a 5-year survival rate of 50% because diagnosis is commonly performed at an advanced stage of the disease, so new diagnostic tools are needed. Nowadays, there is a vast number of publications suggesting the use of salivary biomarkers for oral cancer and potentially malignant disorders diagnosis, but their diagnostic accuracy is unclear. Thus, the goal of this systematic review is to evaluate the diagnostic accuracy of salivary biomarkers for oral cancer and potentially malignant disorders.
Methods
This protocol is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P). We will include primary studies assessing the diagnostic accuracy of salivary biomarkers for oral cancer and potentially malignant disorders. Studies must report data about sensitivity and specificity; gold standard must be the histopathology diagnosis. We will search MEDLINE, EMBASE, the Cochrane Library, and gray literature. Two authors will independently select the studies and extract the data. The methodology quality of studies will be determined using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2).
Expected results and conclusion
Our findings will provide information about the diagnostic accuracy of salivary biomarkers for oral cancer and potentially malignant disorders.
Autores:
Meisser Madera[1,2], Juan Víctor Ariel Franco[3], Ivan Solà[2,4], Xavier Bonfill[2,4], Ingrid Arévalo-Rodriguez[5]
Citación: Madera M, Franco JVA, Solà I, Bonfill X, Arévalo-Rodriguez I. Diagnostic accuracy of salivary biomarkers for oral cancer and potentially malignant disorders: A systematic review protocol . Medwave 2020;20(5):e7938 doi: 10.5867/medwave.2020.05.7938
Fecha de envío: 18/2/2020
Fecha de aceptación: 1/6/2020
Fecha de publicación: 24/6/2020
Origen: No solicitado
Tipo de revisión: Con revisión por pares externa, por tres árbitros a doble ciego
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Brinkmann O, Wong DT. Salivary transcriptome biomarkers in oral squamous cell cancer detection. Adv Clin Chem. 2011;55:21-34. | CrossRef | PubMed |Chan KK, Glenny AM, Weldon JC, Furness S, Worthington HV, Wakeford H. Interventions for the treatment of oral and oropharyngeal cancers: targeted therapy and immunotherapy. Cochrane Database Syst Rev. 2015 Dec 1;(12):CD010341. | CrossRef | PubMed |Freedman ND, Abnet CC, Leitzmann MF, Hollenbeck AR, Schatzkin A. Prospective investigation of the cigarette smoking-head and neck cancer association by sex.Cancer. 2007 Oct 1;110(7):1593-601. | CrossRef | PubMed |Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009 Apr-May;45(4-5):309-16. | CrossRef | PubMed |Conway DI, Petticrew M, Marlborough H, Berthiller J, Hashibe M, Macpherson LM. Socioeconomic inequalities and oral cancer risk: a systematic review and meta-analysis of case-control studies. Int J Cancer. 2008 Jun 15;122(12):2811-9. | CrossRef | PubMed |Madera Anaya M, Franco JVA, Ballesteros M, Solà I, Urrútia Cuchí G, Bonfill Cosp X. Evidence mapping and quality assessment of systematic reviews on therapeutic interventions for oral cancer. Cancer Manag Res. 2018 Dec 24;11:117-130. | CrossRef | PubMed |Yamada SI, Kurita H, Tomioka T, Ohta R, Yoshimura N, Nishimaki F, et al. Healthy life expectancy of oral squamous cell carcinoma patients aged 75years and older. Oral Oncol. 2017 Jan;64:22-26. | CrossRef | PubMed |Wang X, Kaczor-Urbanowicz KE, Wong DT. Salivary biomarkers in cancer detection. Med Oncol. 2017 Jan;34(1):7. | CrossRef | PubMed |
Khurshid Z, Zafar MS, Khan RS, Najeeb S, Slowey PD, Rehman IU. Role of Salivary Biomarkers in Oral Cancer Detection. Adv Clin Chem. 2018;86:23-70. | CrossRef | PubMed |Feng Y, Li Q, Chen J, Yi P, Xu X, Fan Y, et al. Salivary protease spectrum biomarkers of oral cancer. Int J Oral Sci. 2019 Jan 3;11(1):7. | CrossRef | PubMed |Rapado-González Ó, López-López R, López-Cedrún JL, Triana-Martínez G, Muinelo-Romay L, Suárez-Cunqueiro MM. Cell-Free microRNAs as Potential Oral Cancer Biomarkers:From Diagnosis to Therapy. Cells. 2019 Dec 17;8(12):1653. | CrossRef | PubMed |Nagler R, Bahar G, Shpitzer T, Feinmesser R. Concomitant analysis of salivary tumor markers--a new diagnostic tool for oral cancer. Clin Cancer Res. 2006 Jul 1;12(13):3979-84. | CrossRef | PubMed |Kaur J, Jacobs R, Huang Y, Salvo N, Politis C. Salivary biomarkers for oral cancer and pre-cancer screening: a review. Clin Oral Investig. 2018 Mar;22(2):633-640. | CrossRef | PubMed |Hema Shree K, Ramani P, Sherlin H, Sukumaran G, Jeyaraj G, Don KR, et al. Saliva as a Diagnostic Tool in Oral Squamous Cell Carcinoma - a Systematic Review with Meta Analysis. Pathol Oncol Res. 2019 Apr;25(2):447-453. | CrossRef | PubMed |Chattopadhyay I, Panda M. Recent trends of saliva omics biomarkers for the diagnosis and treatment of oral cancer. J Oral Biosci. 2019 Jun;61(2):84-94. | CrossRef | PubMed |Cristaldi M, Mauceri R, Di Fede O, Giuliana G, Campisi G, Panzarella V. Salivary Biomarkers for Oral Squamous Cell Carcinoma Diagnosis and Follow-Up: Current Status and Perspectives. Front Physiol. 2019 Dec 10;10:1476. | CrossRef | PubMed |Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015 Jan 2;350:g7647. | CrossRef | PubMed |WHO. International Classification of Diseases for Oncology. WHO Library Cataloguing-in Publication Data. 2013. [On line] | Link |
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