Palabras clave: hip, hip congenital dislocation, arthroscopy, osteotomy

Introduction

Developmental dysplasia of the hip—also known as congenital hip dysplasia—is a multifactorial disease characterized by an alteration in the development of the acetabulum or the proximal femur[1]. Risk factors like female gender, breech positioning in the third trimester, and family history are poor predictors, so surveillance is mandatory for early diagnosis and treatment to prevent impairing the quality of life[2].

Different screening programs in newborns for congenital hip dysplasia have been proposed. For example, in Chile, congenital hip dysplasia surveillance is performed using a hip radiograph at three months of age for all newborns. It is included in the Explicit Health Guarantees—a set of benefits guaranteed by law allowing access, opportunity, financial protection, and quality of care in a limited list of diseases[3]. Nevertheless, a recent meta-analysis shows insufficient evidence to recommend one strategy over another[4].

Despite efforts, many patients with congenital hip dysplasia are underdiagnosed or remain with residual deformities after physeal closure, so they require medical evaluation for hip pain[5]. The deformities lead to hip instability, increased joint-loading pressures, labral lesion, and osteochondral damage. These patients are at an increased risk to develop osteoarthritis than the general population and patients with other hip pathologies like femoroacetabular impingement[1],[6]. Congenital hip dysplasia is estimated to cause secondary osteoarthrosis by age fifty in 25 percent to 50 percent of patients[7].

Congenital hip dysplasia in patients with a mature skeleton is classified according to the acetabular coverage degree in an anteroposterior pelvic radiograph. The most common angle used is the lateral center-edge angle, also known as the Wiberg angle (Figure 1). The angle is normal between 25° and 40°, being 20-25° a borderline congenital hip dysplasia and less than 20° a true congenital hip dysplasia[8]. 

Figure 1. A 24-year-old woman with severe hip dysplasia.

The treatment for young adults who have symptomatic joint disease aims to prevent or delay osteoarthritis. Non-surgical measurements and joint preservations procedures are treatment options; the last option includes acetabular or femoral osteotomies and hip arthroscopy[9].

The Bernese periacetabular osteotomy is a crucial procedure to restore hip mechanics in patients with true hip dysplasia[10]. This procedure aims to correct the acetabular deformity through a series of bone cuts, which allows the acetabulum to be reoriented in a more medial position and with greater anterior and lateral coverage of the femoral head[11]. The advantages of periacetabular osteotomy compared with other osteotomies are that the posterior hemipelvis remains intact, making the osteotomy more intrinsically stable and allowing for early mobilization weight-bearing. Also, it can be done by a single incision[6].

The ideal patient to undergo periacetabular osteotomy is under 30, without or with slight preoperative osteoarthritis. A survival rate between 60 percent and 90 percent at 20 years after surgery could be expected[12]. However, residual impingement, labrum tears, and chondral injury are potential causes for recurrent symptoms, diminishing quality of life, and revision after periacetabular osteotomy[13],[14]. Patients with hip dysplasia and intraarticular injuries could benefit from performing a concomitant hip arthroscopy along with periacetabular osteotomy[15].

Intraarticular pathology has been reported in association with hip dysplasia[16]. Ross et al.[14] reported the result of 74 periacetabular osteotomies associated with hip arthroscopy performed in one stage. They described 65.8% of a labral lesion, 68.5% of cartilage lesion, and 59.8% of combined lesions. Matheney et al.[13] report a cohort of 135 periacetabular osteotomies, where 11% has to be revised with hip arthroscopy for a labral lesion. This subgroup of patients could benefit from a hip arthroscopy when there is a repairable intraarticular injury.

There is no consensus if intra-articular pathology should be addressed before, simultaneously, or after periacetabular osteotomy[16]. Several studies report improvement and good clinical results for isolated arthroscopy for mild dysplasia and good results after periacetabular osteotomy for severe hip dysplasia. Still, few studies report the results of both procedures concomitantly[17],[18].

The purpose of this study is to describe patient-reported outcomes, radiological results, and revision to total hip replacement in patients with hip dysplasia that underwent periacetabular osteotomy as isolated treatment or concomitant with hip arthroscopy.

Methods

We performed a case series of consecutive patients that required periacetabular osteotomy for hip dysplasia between 2014 and 2017. Patients were included if they complained of hip pain that compromised their quality of life without response to medical treatment and if an anteroposterior pelvis radiograph demonstrates a Wiberg angle less than 20°. Exclusion criteria were an in-maturate skeleton, age 40 or older, previous hip surgery, concomitant connective tissue disease, and Tönnis osteoarthritis grade 1 or more. The local ethics committee board approved this study. All patients gave written consent prior to surgery and at the final follow-up when they completed the patient-reported outcome survey.

Before surgery, all patients underwent anteroposterior pelvis and false-profile radiographs and hip magnetic resonance imaging. In the anteroposterior pelvis view, the Wiberg angle, Tönnis Angle, and extrusion index were measured; in the false-profile view, the anterior center-edge angle was measured[19],[20]. Both radiographic views performed were retaken after surgery, and the same angles were recorded (Figure 1). Magnetic resonance imaging was used to assess intraarticular lesions, and if a labral tear or focal chondral lesion was found, concomitant hip arthroscopy was performed.

A senior hip surgeon performed all procedures. If a hip arthroscopy was performed, the patient was positioned supine in a traction table with a well-padded perineal post[21]. Under fluoroscopy, the hip seal was broken, and traction was applied. Anterolateral and mid-anterior portals were created[22]. An in-between portal capsulotomy is performed, then a systematic diagnostic arthroscopic is done with a 70° four millimeters arthroscope. The labrum and cartilage status are carefully assessed, and if present, chondral acetabular lesions are described according to the Beck et al. classification[23]. Only minimal acetabuloplasty is carried-out in cases that require labrum repair with anchors; otherwise, no acetabuloplasty is performed. In all cases, the capsule was closed.

After hip arthroscopy, and in the same anesthesia, the patient is placed supine in the radiolucent table. Periacetabular osteotomy is performed as described by Ganz et al.[11] and modified by Maldonado et al.[24]. An anterior hip approach is used; superficial dissection is performed with caution to minimize injury to the lateral femoral cutaneous nerve. The ischium and pubis are identified by developing an interval between the medial joint capsule and psoas muscle. After that, an incomplete osteotomy of the ischium, followed by a complete osteotomy of the pubis, is performed. The Iliac bone is then exposed, and an incomplete osteotomy from just below the anterior superior iliac spine to the pelvic brim is performed. The final bone cut is done to connect the third cut with the ischium osteotomy (first cut), allowing for the fragment mobilization to perform the desired correction under fluoroscopy guidance. Once the desired correction is achieved, the fragment is temporarily fixed, and the hip is bent up to 90 degrees to assess the presence of impingement. Finally, the fragment is held with at least three 4.5-millimeter fully threaded screws. If any impingement is noted with a flexion adduction internal rotation maneuvers, an open femoral osteochrondroplasty is performed.

Rehabilitation begins the first day after surgery, guided by a physiotherapist. Partial weight-bearing with two canes and a range of motion between zero to 90 degrees of hip flexion is allowed. After four weeks, full weight-bearing is encouraged. Patients can resume running between six to nine months depending on the degree of consolidation and muscle status.

The patient functional reported outcome was evaluated with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)[25] and the Hip disability and Osteoarthritis Outcome Score (HOOS)[26]. Patients were contacted by telephone in-between the 12 to 18 months after surgery by a hip fellow resident. The minimum follow-up in the clinical record was 24 months.

Continuous variables are summarized in median, range, and interquartile range (p25 to p75), and absolute frequency and percent was used for discrete variables. Non-parametric median test for paired data was used to compare radiological measurements after and before surgery. Radiological measurements and functional outcomes are compared between periacetabular osteotomy alone and a mix of periacetabular osteotomy and hip arthroscopy, using a non-parametric median test for unpaired data. Survival analysis was performed using revision to total hip arthroplasty as a failure. The Kaplan Meier curve was estimated. The data were processed using Stata version 15 (StataCorp LP, College Station, Texas, USA).

Results

A total of fifteen consecutive patients were included, fourteen of which (93%) were female patients, and one was male (0.7%). The median age was 20 (range, 13 to 32). Four patients (27%) underwent bilateral surgery, and the waiting time for the second procedure was three months in one case and 12 months for the other three patients. Seven patients (47%) underwent concomitant hip arthroscopy; three of them (47%) were bilateral (10 hips). Demographic data between periacetabular osteotomy plus hip arthroscopy group and isolated periacetabular osteotomy is compared in Table 1.

Table 1. Demographic data.

Preoperative median Wiberg angle was 12° (range, -29° to 19°) and a median correction of 16° (range, 7° to 53°) was achieved after periacetabular osteotomy, which was significant (p = 0.001) (see Table 2). The postoperative median Wiberg angle was 25° (range, 8° to 34°). In the anterior center-edge angle, the median correction was lower than in the Wiberg angle, reaching 8° (range, 0° to 20°) without statical significance (Table 2). Median Tönnis angle and extrusion index correction was 14° (range, 1° to 32°) and 19% (range, 4% to 32%) respectively; both measurements reached significant statistical difference (Table 2). The comparison between periacetabular osteotomy and periacetabular osteotomy plus hip arthroscopy is summarized in Table 3, and only the anterior center-edge angle correction reached statistical difference.

Table 2. Radiological measurement before and after surgery. LCEA, ACEA, Tönnis angle, and extrusion index reached a significant difference after surgery.

Table 3. Radiological measurement before and after surgery by the group of treatment.

In the hip arthroscopy group, nine out of the ten hips had a labrum tear; in six cases (60%), it was detached and required labrum repair with anchors. In seven cases, the labrum was hyperplastic, and in three cases, it was degenerative. Also, a cartilage lesion was identified in seven (70%) cases. Five of them (50%) had a carpet phenomenon (also known as "wave sign") and were classified as a Beck type two lesion. In one case, the acetabular cartilage was rough and fibrillated (Beck type one lesion), and one case had a Beck type 3 lesion with a deep and extended flap. This last patient was the only one of this group that required revision to a total hip replacement. No femoral osteochrondroplasty, acetabuloplasty, or psoas release was performed in any case. No hip arthroscopy-related complications are reported in this series.

Patients reported a median of 130 points (range, 93 to 151) in the HOOS scale and of 86 points (range, 62 to 96) in the WOMAC scale. In Table 4, both functional scales are summarized by groups of treatment, and no significant difference was found.

Table 4. Functional scores 12 to 18 months after surgery are shown. No statically difference was found between the groups of treatment.

The total cohort time at risk was 75 years. The median follow-up was 3.5 years (range, 2 to 8 years), which reached a survival of 0.85 (95% confidence interval: 0.51 to 0.96) (Figure 2). A total of three hips (16%) were revised to total hip arthroplasty (3 patients, 20%), two of which from the periacetabular osteotomy alone group. The incidence rate of failure was 0.039 per year.

Figure 2. Kaplan Meier survival estimate of the total cohort.

Discussion

This case series shows a significant correction of Wiberg angle, Tönnis angle, and extrusion index after periacetabular osteotomy, adding to the vast literature on good to excellent results in periacetabular osteotomy for hip dysplasia. Remarkably, this study shows that the amount of correction and the functional outcome is not significantly different between periacetabular osteotomy alone and periacetabular osteotomy plus hip arthroscopy. Also, no significant increase in complications or failure rate in the hip arthroscopy plus periacetabular osteotomy is reported.

A recent meta-analysis showed a paucity in reports of outcomes after periacetabular osteotomy plus hip arthroscopy so that no reliable conclusions could be made[18]. Nevertheless, it seems logical to include hip arthroscopy in the setting of periacetabular osteotomy if any intraarticular lesion is suspected or confirmed by imaging, as no study had shown an increase of complication compared to periacetabular osteotomy alone. Nowadays, a case by case decision basis seems more appropriate to design a comprehensive treatment strategy in the dysplastic population[17].

Intraarticular lesions are frequent in dysplastic patients[27], and hip arthroscopy is a powerful minimally invasive technique to address these lesions. Two main questions remain unclear to recommend hip arthroscopy concomitant with periacetabular osteotomy. First, is a failure after periacetabular osteotomy due to inadequate correction leading to impingement (overcorrection) or instability (under-correction)? Alternatively, failure is due to leave-alone intraarticular lesions like a labrum tear? The second question is, which intraarticular lesion and intraarticular procedure improve clinical outcomes after periacetabular osteotomy? Overcorrection should always be avoided, but under correction could occur unintentionally due to low volume acetabulum. Hip arthroscopy alone has demonstrated good mid-term functional results for borderline dysplasia[28], and special attention in this type of patients must be made to the capsular management to avoid instability[29]. Labrum and capsule have a crucial role in hip stability[30]; specifically, biomechanical studies have shown that iliofemoral ligament is a primary restrictor and labrum a secondary restrictor to external rotation and anterior translation of the femur[31]. Since the acetabular volume in dysplasia is lower than in normal patients, a perfect correction of acetabular coverage is not always possible, putting at risk of micro instability to the hip. If unintended under coverage, a labral tear or poor management of the capsule is added to this, the instability may increase, causing the osteotomy's early failure. Therefore, acetabular volume and under-correction could play a crucial to decide if intraarticular lesions should be addressed.

Chondral lesions are frequent in hip dysplasia, and even it has been described that a particular type of injury called "Outside-In Flap" is characteristic of chondral damage in hip dysplasia[32]. The presence of cartilage lesion jeopardizes the outcome of periacetabular osteotomy[13]; nevertheless, articular procedures like microfracture or chondroplasty when a high-grade chondral lesion is present have not achieved good outcome[33],[34],[35],[36], so it makes it difficult to perform a reliable conclusion about indication concomitant with periacetabular osteotomy.

Our comprehensive treatment strategy is always to perform a hip arthroscopy when a labral tear is shown in the magnetic resonance imaging. The first option is to repair the tear, as consistent better long-term results are achieved compared to labral resection[37]. If repair is not possible, labral reconstruction with iliotibial band graft is performed[38].

This study's limitations are that it is a low volume cohort and has no control group. Nevertheless, it contributes to the increasing trend to address intraarticular lesions seeking improvement in periacetabular osteotomy functional outcome and survival. Another limitation of this study is that the preoperative WOMAC and HOOS were not available. Finally,  due to the design of the study, it is no possible to compare the functional outcomes between groups as the patients were intentionally selected according to the presence of an intraarticular lesion. However, considering that patients with intraarticular lesions are in a more advanced stage of hip dysplasia, to obtain similar functional results adding hip arthroscopy is a remarkable finding.

Conclusions

To perform a hip arthroscopy concomitant with periacetabular osteotomy does not increase the complication rate and did not affect the acetabular correction or clinical result. We recommend adding hip arthroscopy to periacetabular osteotomy when magnetic resonance imaging shows an intraarticular lesion as hip arthroscopy does not affect periacetabular osteotomy results outcomes of complications, alignment, and clinical outcome.

Meta-analyses and systematic reviews have not given a final recommendation on adding hip arthroscopy to periacetabular osteotomy due to the lack of evidence at present. Therefore, a case by case decision basis seems more appropriate to design a comprehensive treatment strategy in hip dysplasia. Particular attention should be taken when there is a high risk of low correction due to a low volume acetabulum, and magnetic resonance imaging shows a lesion of the labrum, given the high risk of instability if the labrum is not repaired. 

Notes

Roles and contributions of authorship
CB: Conceptualization, formal analysis, writing (review and editing), supervision and project administration. JB: Conceptualization, formal analysis. RO, RW: Investigation and writing (original draft preparation). AM: Investigation, formal analysis, writing (review and editing), supervision.
JH: Writing (original draft preparation) and visualization. MB: Methodology, formal analysis, writing (original draft preparation, review and editing). 

Conflicts of interest
The authors declare that they have no competing interests.

Funding
There was no funding for this research.

Ethics approval
This study was approved by the Hospital Clínico Universidad de Chile ethics research board, as stated in certificate number 18, issued on May 6, 2020.

Availability of data
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Figure 1. A 24-year-old woman with severe hip dysplasia.

Table 1. Demographic data.

Table 2. Radiological measurement before and after surgery. LCEA, ACEA, Tönnis angle, and extrusion index reached a significant difference after surgery.

Table 3. Radiological measurement before and after surgery by the group of treatment.

Table 4. Functional scores 12 to 18 months after surgery are shown. No statically difference was found between the groups of treatment.

Figure 2. Kaplan Meier survival estimate of the total cohort.

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