Peer-reviewed general biomedical journal
Case Report
Medwave 2015 Nov;15(10):e6323 doi: 10.5867/medwave.2015.10.6323
Intravenous immunoglobulin therapy in Morvan syndrome secondary to recurrent thymic carcinoma
Gabriel Horta Baas
Key Words: Morvan's syndrome, intravenous immunoglobulins, thymic carcinoma, thymoma
Abstract
Morvan's syndrome is a rare autoimmune channelopathy. A case of Morvan's syndrome is presented as a paraneoplastic syndrome associated to the recurrence of a well-differentiated thymic carcinoma, which showed a good clinical response to treatment with intravenous immunoglobulin.
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El síndrome de Morvan es una canalopatía rara de origen autoinmune. Se presenta el caso de un síndrome de Morvan como una entidad paraneoplásica asociada a la recurrencia de un carcinoma tímico bien diferenciado, el cual presentó una buena respuesta clínica al tratamiento con inmunoglobulina intravenosa.
Autores:
Gabriel Horta Baas[1]
Affiliation:
[1] Servicio de Medicina Interna, Unidad Médica de Alta Especialidad, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México
E-mail: gabho@hotmail.com
Author address:
[1] Belisario Domínguez 1000
Colonia Independencia Oriente
Guadalajara
Jalisco
México
Citation: Horta Baas G. Intravenous immunoglobulin therapy in Morvan syndrome secondary to recurrent thymic carcinoma. Medwave 2015 Nov;15(10):e6323 doi: 10.5867/medwave.2015.10.6323
Submission date: 4/5/2015
Acceptance date: 7/11/2015
Publication date: 25/11/2015
Origin: not requested
Type of review: reviewed by four external peer reviewers, double-blind
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- Ruggieri VL, Arberas CL. [Neuromuscular hereditary channelopathies: non-dystrophic myotonias, paramyotonias and periodic paralysis]. Rev Neurol. 2002 Jan 16-31;34(2):150-6. | PubMed |
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- Gállego Pérez-Larraya J, Dalmau J. [Classic paraneoplastic syndromes: diagnostic and treatment approach]. Neurologia. 2008 Sep;23(7):441-8. | PubMed |
- Montojo MT, Petit-Pedrol M, Graus F, Dalmau J. Clinical spectrum and diagnostic value of antibodies against the potassium channel related protein complex. Neurologia. 2015 Jun;30(5):295-301. | CrossRef | PubMed |
- Merchut MP. Management of voltage-gated potassium channel antibody disorders. Neurol Clin. 2010 Nov;28(4):941-59. | CrossRef | PubMed |
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- Cottrell DA, Blackmore KJ, Fawcett PR, Birchall D, Vincent A, Barnard S,et al. Sub-acute presentation of Morvan's syndrome after thymectomy. J Neurol Neurosurg Psychiatry. 2004 Oct;75(10):1504-5. | PubMed |
- Bataller L, Dalmau J. Paraneoplastic neurologic syndromes. Neurol Clin N Am. 21:221-227. | CrossRef |
- van den Berg JS, van Engelen BG, Boerman RH, de Baets MH. Acquired neuromyotonia: superiority of plasma exchange over high-dose intravenous human immunoglobulin. J Neurol. 1999 Jul;246(7):623-5. | PubMed |
- Graves D, Vernino S. Immunotherapies in neurologic disorders. Med Clin North Am. 2012 May;96(3):497-523, x. | CrossRef | PubMed |
- Skeie GO, Apostolski S, Evoli A, Gilhus NE, Hart IK, Harms L, et al. Guidelines for the treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol. 2006 Jul;13(7):691-9. | PubMed |
- Kivity S, Katz U, Daniel N, Nussinovitch U, Papageorgiou N, Shoenfeld Y. Evidence for the use of intravenous immunoglobulins--a review of the literature. Clin Rev Allergy Immunol. 2010 Apr;38(2-3):201-69. | CrossRef | PubMed |
- Bayry J, Negi VS, Kaveri SV. Intravenous immunoglobulin therapy in rheumatic diseases. Nat Rev Rheumatol. 2011 Jun;7(6):349-59. | CrossRef | PubMed |
- Ho WK, Wilson JD. Hypothermia, hyperhidrosis, myokymia and increased urinary excretion of catecholamines associated with a thymoma. Med J Aust. 1993 Jun 7;158(11):787-8. | PubMed |
- Alessi G, De Reuck J, De Bleecker J, Vancayzeele S. Successful immunoglobulin treatment in a patient with neuromyotonia. Clin Neurol Neurosurg. 2000 Sep;102(3):173-5. | PubMed |
Ruggieri VL, Arberas CL. [Neuromuscular hereditary channelopathies: non-dystrophic myotonias, paramyotonias and periodic paralysis]. Rev Neurol. 2002 Jan 16-31;34(2):150-6. | PubMed |Irani SR, Pettingill P, Kleopa KA, Schiza N, Waters P, Mazia C, et al. Morvan syndrome: clinical and serological observations in 29 cases. Ann Neurol. 2012 Aug;72(2):241-55. | CrossRef | PubMed |Lee W, Day TJ, Williams DR. Clinical, laboratory and electrophysiological features of Morvan's fibrillary chorea. J Clin Neurosci. 2013 Sep;20(9):1246-9. | CrossRef | PubMed |Panagariya A, Kumar H, Mathew V, Sharma B. Neuromyotonia: clinical profile of twenty cases from northwest India. Neurol India. 2006 Dec;54(4):382-6. | PubMed |Liguori R, Vincent A, Clover L, Avoni P, Plazzi G, Cortelli P, et al. Morvan's syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels. Brain. 2001 Dec;124(Pt 12):2417-26. | PubMed |Gállego Pérez-Larraya J, Dalmau J. [Classic paraneoplastic syndromes: diagnostic and treatment approach]. Neurologia. 2008 Sep;23(7):441-8. | PubMed |Montojo MT, Petit-Pedrol M, Graus F, Dalmau J. Clinical spectrum and diagnostic value of antibodies against the potassium channel related protein complex. Neurologia. 2015 Jun;30(5):295-301. | CrossRef | PubMed |Merchut MP. Management of voltage-gated potassium channel antibody disorders. Neurol Clin. 2010 Nov;28(4):941-59. | CrossRef | PubMed |Abou-Zeid E, Boursoulian LJ, Metzer WS, Gundogdu B. Morvan syndrome: a case report and review of the literature. J Clin Neuromuscul Dis. 2012 Jun;13(4):214-27. | CrossRef | PubMed |Cottrell DA, Blackmore KJ, Fawcett PR, Birchall D, Vincent A, Barnard S,et al. Sub-acute presentation of Morvan's syndrome after thymectomy. J Neurol Neurosurg Psychiatry. 2004 Oct;75(10):1504-5. | PubMed |Bataller L, Dalmau J. Paraneoplastic neurologic syndromes. Neurol Clin N Am. 21:221-227. | CrossRef |van den Berg JS, van Engelen BG, Boerman RH, de Baets MH. Acquired neuromyotonia: superiority of plasma exchange over high-dose intravenous human immunoglobulin. J Neurol. 1999 Jul;246(7):623-5. | PubMed |Graves D, Vernino S. Immunotherapies in neurologic disorders. Med Clin North Am. 2012 May;96(3):497-523, x. | CrossRef | PubMed |Skeie GO, Apostolski S, Evoli A, Gilhus NE, Hart IK, Harms L, et al. Guidelines for the treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol. 2006 Jul;13(7):691-9. | PubMed |Kivity S, Katz U, Daniel N, Nussinovitch U, Papageorgiou N, Shoenfeld Y. Evidence for the use of intravenous immunoglobulins--a review of the literature. Clin Rev Allergy Immunol. 2010 Apr;38(2-3):201-69. | CrossRef | PubMed |Bayry J, Negi VS, Kaveri SV. Intravenous immunoglobulin therapy in rheumatic diseases. Nat Rev Rheumatol. 2011 Jun;7(6):349-59. | CrossRef | PubMed |Ho WK, Wilson JD. Hypothermia, hyperhidrosis, myokymia and increased urinary excretion of catecholamines associated with a thymoma. Med J Aust. 1993 Jun 7;158(11):787-8. | PubMed |Alessi G, De Reuck J, De Bleecker J, Vancayzeele S. Successful immunoglobulin treatment in a patient with neuromyotonia. Clin Neurol Neurosurg. 2000 Sep;102(3):173-5. | PubMed |
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