Consensus
Medwave 2020;20(8):e8012 doi: 10.5867/medwave.2020.08.8012
Reducing the impact of COVID-19 on radiation oncology units of developing countries: A rapid review and expert consensus
Nadia Montero-Oleas, Raúl Puente-Vallejo, Bárbara León-Micheli, Andrés Imbaquingo-Cabrera, Mónica Silva, Elizabeth Gamarra, Byron Álvarez-Rodas, Nelson Segovia, Pablo Aldaz-Roldan, Cristina Nuñez-Silva, Karina Zurita-Vivero, Alex Carrión, José Molina-Jaramillo, Andrés Rodríguez-Balarezo, Yuri Betancourt, Luis De Los Reyes
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Key Words: radiotherapy, COVID-19, coronavirus, hypofractionated, pandemic, cancer

Abstract

Objective
To generate recommendations on the management of radiotherapeutic treatments during the pandemic, adapted to a country with limited health resources.

Methods
We did a rapid review of the literature, searching for papers that describe any measures to reduce the risk of COVID-19 infection, as well as management guidelines to reduce the workload, in radiotherapy units. The following conditions were included in the scope of this review: gynecological tumors, breast cancer, gastrointestinal tumors, genitourinary tumors, head and neck tumors, skin cancer, tumors of the central nervous system, and lymphomas. An expert group discussed online the extracted data and drafted the recommendations. Using a modified Delphi method, the consensus was reached among 14 certificated radio-oncologists. The quality of the evidence that supported the recommendations on treatment schedules was assessed.

Results
A total of 57 documents were included. Of these, 25 provided strategies to reduce the risk of infection. Recommendations for each condiction were extracted from the remaining documents. The recommendations aim to establish specific parameters where treatments can be omitted, deferred, prioritized, and shortened. Treatment schemes are recommended for each condition, prioritizing hypo-fractionated schemes whenever possible.

Conclusions
We propose strategies for the management of radiotherapy services to guarantee the continuity of high-quality treatments despite the health crisis caused by COVID-19.


 

No English version is available for this article.

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Objetivo
Establecer recomendaciones para la toma de decisiones de manejo en radioterapia durante la pandemia de COVID-19, adaptadas a un país con recursos de salud limitados.

Métodos
A través de una revisión rápida de la literatura se buscaron publicaciones que describieran medidas para reducir el riesgo de infección por COVID-19, así como también pautas de manejo para reducir la carga de trabajo en las unidades de radioterapia. Se incluyeron en el alcance de esta revisión las siguientes patologías: tumores ginecológicos, cáncer de mama, tumores gastrointestinales, tumores genitourinarios, tumores de cabeza y cuello, cáncer de piel, tumores del sistema nervioso central y linfomas. Un grupo de expertos discutió en línea los datos extraídos y redactó las recomendaciones. Mediante un método Delphi modificado, se evaluó el consenso entre 14 radio-oncólogos certificados. Se evaluó la calidad de la evidencia que sustentó las recomendaciones sobre esquemas de tratamiento.

Resultados
Se incluyeron un total de 57 documentos. De 25 trabajos se extrajeron las estrategias para reducir el riesgo de infección. De los restantes, se obtuvieron las recomendaciones para cada patología. Las recomendaciones están orientadas a establecer escenarios específicos donde se pueden omitir, diferir, priorizar y acortar los tratamientos. En el ítem de acortar se recomiendan esquemas de tratamiento para cada patología, priorizando los esquemas hipofraccionados cuando fue posible.

Conclusión
Se plantean estrategias para la gestión de los servicios de radioterapia con el objetivo de garantizar que los tratamientos de alta calidad para pacientes oncológicos sigan entregándose, pese a la crisis sanitaria ocasionada por COVID-19.

Authors: Nadia Montero-Oleas[1], Raúl Puente-Vallejo[2], Bárbara León-Micheli[3], Andrés Imbaquingo-Cabrera[2], Mónica Silva[4], Elizabeth Gamarra[5], Byron Álvarez-Rodas[6], Nelson Segovia[3], Pablo Aldaz-Roldan[7], Cristina Nuñez-Silva[2], Karina Zurita-Vivero[2], Alex Carrión[2], José Molina-Jaramillo[6], Andrés Rodríguez-Balarezo[8], Yuri Betancourt[1], Luis De Los Reyes[2]

Affiliation:
[1] Posgrado de Radioterapia, Facultad de Ciencias Médicas, Universidad Central del Ecuador, Quito, Ecuador
[2] Departamento de Radioterapia, Hospital Oncológico SOLCA Núcleo de Quito, Quito, Ecuador
[3] Facultad de Ciencias Médicas, Universidad Central del Ecuador, Quito, Ecuador
[4] Servicio de Radioterapia, SOLCA Manabí, Núcleo Portoviejo, Portoviejo, Ecuador
[5] Departamento de Radio-Oncología, Instituto Oncológico Nacional Dr. Juan Tanca Marengo, SOLCA-Guayaquil, Guayaquil, Ecuador
[6] Unidad Académica de Salud y Bienestar, Universidad Católica de Cuenca, Cuenca, Ecuador
[7] Escuela de Medicina, Departamento de Ciencias de la Salud, Universidad Técnica Particular de Loja, Loja, Ecuador
[8] Unidad de Radioterapia, Hospital de Especialidades José Carrasco Arteaga, Cuenca, Ecuador

E-mail: nadiamonteromd@gmail.com

Author address:
[1] José Félix Barreiro E15-242
Quito, Ecuador
Código postal: 170209 San Isidro del Inca

Citation: Montero-Oleas N, Puente-Vallejo R, León-Micheli B, Imbaquingo-Cabrera A, Silva M, Gamarra E, et al. Reducing the impact of COVID-19 on radiation oncology units of developing countries: A rapid review and expert consensus. Medwave 2020;20(8):e8012 doi: 10.5867/medwave.2020.08.8012

Submission date: 25/5/2020

Acceptance date: 11/8/2020

Publication date: 7/9/2020

Origin: Not commissioned

Type of review: Externally peer-reviewed by three reviewers, double-blind

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  1. World Health Organization. Coronavirus disease. Situation Report 166.2020. [On line] | Link |
  2. Muñoz N. COVID-19 in Latin America: a first glance to the mortality. Colomb Med. 2020; 51(2). | CrossRef |
  3. El-Shakankery KH, Kefas J, Crusz SM. Caring for our cancer patients in the wake of COVID-19. Br J Cancer. 2020 Jul;123(1):3-4. | CrossRef | PubMed |
  4. Liang W, Guan W, Chen R, Wang W, Li J, Xu K, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020 Mar;21(3):335-337. | CrossRef | PubMed |
  5. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak. Cancer Discov. 2020 Jun;10(6):783-791. | CrossRef | PubMed |
  6. Yap ML, Hanna TP, Shafiq J, Ferlay J, Bray F, Delaney GP, et al. The Benefits of Providing External Beam Radiotherapy in Low- and Middle-income Countries. Clin Oncol (R Coll Radiol). 2017 Feb;29(2):72-83. | CrossRef | PubMed |
  7. Zaorsky NG, Yu JB, McBride SM, Dess RT, Jackson WC, Mahal BA, et al. Prostate Cancer Radiation Therapy Recommendations in Response to COVID-19. Adv Radiat Oncol. 2020 Apr 1;5(4):659-665. | CrossRef | PubMed |
  8. Varker T, Forbes D, Dell L, Weston A, Merlin T, Hodson S, et al. Rapid evidence assessment: increasing the transparency of an emerging methodology. J Eval Clin Pract. 2015 Dec;21(6):1199-204. | CrossRef | PubMed |
  9. Loblaw DA, Prestrud AA, Somerfield MR, Oliver TK, Brouwers MC, Nam RK, et al. American Society of Clinical Oncology Clinical Practice Guidelines: formal systematic review-based consensus methodology. J Clin Oncol. 2012 Sep 1;30(25):3136-40. | CrossRef | PubMed |
  10. The Royal College of Radiologist. PRINCIPLES FOR RADIATION THERAPY SERVICES DURING COVID19. [On line] | Link |
  11. Achard V, Tsoutsou P, Zilli T. Radiotherapy in the time of the Coronavirus pandemic: when less is better. Int J Radiat Oncol Biol Phys. 2020 Jul 1;107(3):600-601.
  12. Provincial Health Services Authority. Provincial Cancer Clinical Management Guidelines in Pandemic Situation ( COVID-19 ). 2020. [On line] | Link |
  13. Chen W, Su XY, Wang VJ, Wang EC, Xu R, Zhong S, et al. Novel Coronavirus International Public Health Emergency: Guidance on Radiation Oncology Facility Operation. Adv Radiat Oncol. 2020 Apr 1;5(4):560-566. | CrossRef | PubMed |
  14. Chen YL, Hsu FM, Tsai CJ, Cheng JC. Efforts to Reduce the Impact of Coronavirus Disease 2019 Outbreak on Radiation Oncology in Taiwan. Adv Radiat Oncol. 2020 Apr 6;5(4):534-537. | CrossRef | PubMed |
  15. Dinh TT, Halasz LM, Ford E, Rengan R. Radiation Therapy in King County, Washington During the COVID-19 Pandemic: Balancing Patient Care, TransmissionMitigation, and Resident Training. Adv Radiat Oncol. 2020 Mar 27;5(4):544-547. | CrossRef | PubMed |
  16. Filippi AR, Russi E, Magrini SM, Corvò R. Letter from Italy: First practical indications for radiation therapy departments during COVID-19 outbreak. Int J Radiat Oncol Biol Phys. 2020 Jul 1;107(3):597-599. | CrossRef | PubMed |
  17. Krengli M, Ferrara E, Mastroleo F, Brambilla M, Ricardi U. Running a Radiation Oncology Department at the Time of Coronavirus: An Italian Experience. Adv Radiat Oncol. 2020 Mar 20;5(4):527-530. | CrossRef | PubMed |
  18. Sociedad Española de Oncología Médica, Sociedad Española de Oncología Radioterápica. Documento técnico Recomendaciones para el manejo , prevención y control de COVID-19 en los hospitales de día onco-hematológicos y servicios de oncología radioterápica. 2020. [On line] | Link |
  19. Mukherjee RK, Back MF, Lu JJ, Shakespeare TP, Wynne CJ. Hiding in the bunker: Challenges for a radiation oncology department operating in the Severe Acute Respiratory Syndrome outbreak. Australas Radiol. 2003 Jun;47(2):143-5. | CrossRef | PubMed |
  20. National Institute for Health and Care Excellence. COVID-19 rapid guideline: delivery of radiotherapy. 2020;1–15.[On line] | Link |
  21. Papachristofilou A, Finazzi T, Kohler G, Dott C, Zimmermann F. Contingency Plans in a Radiation Oncology Department Amid the 2019-nCoV Outbreak in Switzerland. Adv Radiat Oncol. 2020 Mar 31;5(4):577-581. | CrossRef | PubMed |
  22. Peter MacCallum Cancer Centre. COVID-19 Clinical Services Response Plan - DRO - March 2020 V3. 2020.[On line] | Link |
  23. Rao YJ, Provenzano D, Gay HA, Read PW, Ojong M, Goyal S. A Radiation Oncology Departmental Policy for the 2019 Novel Coronavirus (COVID-19) Pandemic. Preprints 2020:1–17. | CrossRef |
  24. Rivera A, Ohri N, Thomas E, Miller R, Knoll MA. The Impact of COVID-19 on Radiation Oncology Clinics and Patients With Cancer in the United States. Adv Radiat Oncol. 2020 Mar 27;5(4):538-543. | CrossRef | PubMed |
  25. Sociedad Española de Oncología Radioterapica. Recomendaciones Generales ante la situación de pandemia por COVID-19 en el área de Oncología Radioterápica. 2020.[On line] | Link |
  26. Simcock R, Thomas TV, Estes C, Filippi AR, Katz MA, Pereira IJ, et al. COVID-19: Global radiation oncology's targeted response for pandemic preparedness. Clin Transl Radiat Oncol. 2020 Mar 24;22:55-68. | CrossRef | PubMed |
  27. Wright JL, Alcorn SR, McNutt T, Han-Oh S, Gonzalez R, Lin L, et al. An Integrated Program in a Pandemic: Johns Hopkins Radiation Oncology Department. Adv Radiat Oncol. 2020 Apr 9;5(4):666-672. | CrossRef | PubMed |
  28. Wu S, Zheng D, Liu Y, Hu D, Wei W, Han G. Radiation Therapy Care During a Major Outbreak of COVID-19 in Wuhan. Adv Radiat Oncol. 2020 Mar 27;5(4):531-533. | CrossRef | PubMed |
  29. Mascarin M, Coassin E, Provenzi M, Franchin G, Mariotto A. How to Reorganize Children's Access to Radiation Therapy in the Era of COVID-19, to Protect Them and Elderly Patients. Adv Radiat Oncol. 2020 Apr 11;5(4):673-674. | CrossRef | PubMed |
  30. Lu JJ. Experience of a Radiation Oncology Center Operating During the COVID-19 Outbreak. Adv Radiat Oncol. 2020 Apr 10;5(4):548-549. | CrossRef | PubMed |
  31. Samiee S, Hadjilooei F, Alamolhoda M, Akhlaghpoor S. New Policy and Regulations for a Radiology-Oncology Center During the COVID-19 Outbreak in Tehran, Iran. Adv Radiat Oncol. 2020 Apr 14;5(4):550-557. | CrossRef | PubMed |
  32. Wei W, Zheng D, Lei Y, Wu S, Verma V, Liu Y, et al. Radiotherapy workflow and protection procedures during the Coronavirus Disease 2019 (COVID-19) outbreak: Experience of the Hubei Cancer Hospital in Wuhan, China. Radiother Oncol. 2020 Jul;148:203-210. | CrossRef | PubMed |
  33. Wei W, Jiang H, Chen W, Zhou Y, Guo S, Zhong G, et al. How should we implement radiotherapy for cancer patients in China during the endemic period of COVID-19? Radiother Oncol. 2020 Jun;147:100-102. | CrossRef | PubMed |
  34. Tey J, Ho S, Choo BA, Ho F, Yap SP, Tuan JKL, et al. Navigating the challenges of the COVID-19 outbreak: Perspectives from the radiation oncology service in Singapore. Radiother Oncol. 2020 Jul;148:189-193. | CrossRef | PubMed |
  35. De Felice F, Polimeni A, Tombolini V. The impact of Coronavirus (COVID-19) on head and neck cancer patients' care. Radiother Oncol. 2020 Jun;147:84-85. | CrossRef | PubMed |
  36. Gay HA, Santiago R, Gil B, Remedios C, Montes PJ, López-Araujo J, et al. Lessons Learned From Hurricane Maria in Puerto Rico: Practical Measures to Mitigate the Impact of a Catastrophic Natural Disaster on Radiation Oncology Patients. Pract Radiat Oncol. 2019 Sep-Oct;9(5):305-321. | CrossRef | PubMed |
  37. Roques T, Prestwich R. Head and neck cancer and COVID-19. The Royal College of Radiologist. 2020. [On line] | Link |
  38. Yale School of Medicine Department of Therapeutic Radiology faculty. COVID19 Yale Radiation Oncology Flowchart –. 2020. | Link |
  39. Thomson DJ, Palma D, Guckenberger M, Balermpas P, Beitler JJ, Blanchard P, et al. Practice Recommendations for Risk- Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic: An ASTRO-ESTRO Consensus Statement. Int J Radiat Oncol Biol Phys. 2020 Jul 15;107(4):618-627 | CrossRef | PubMed |
  40. De Felice F, Petrucciani N. Treatment approach in locally advanced rectal cancer during coronavirus (COVID-19) pandemic: long course or short course? Colorectal Dis. 2020 Jun;22(6):642-643. | CrossRef | PubMed |
  41. Marijnen CAM, Peters FP, Rödel C, Bujko K, Haustermans K, Fokas E, et al. International expert consensus statement regarding radiotherapy treatment options for rectal cancer during the COVID 19 pandemic. Radiother Oncol. 2020 Jul;148:213-215. | CrossRef | PubMed |
  42. Oxford Colorrectal Oncologists. Lower GI response to Covid-19 outbreak. 2020;:1–2.[On line] | Link |
  43. Grose D, Hunt A, Katharine Aitken, Mukherjee S, Hawkins M, Radhakrishna G, et al. RADIOTHERAPY PROTOCOL : Radical Pancreas 15 fraction ( adapted from PRIMUS 002 radiotherapy protocol and RMH research protocol ). The Royal College of Radiologists. 2020. [On line] | Link |
  44. Mukjerjee S, Hawkins M, Aitkin K, Radhakrishna G, Gose D, Godoy R, et al. Hypofractionated Radical Pancreas (5 fraction) (adapted from Oxford Protocol and SPARC trial). 2020. [On line] | Link |
  45. Mukherjee S, Jones C. Considerations for treatment of pancreatic cancer within the United Kingdom during the COVID-19 pandemic.[On line] | Link |
  46. Sociedad Española de Oncología Radioterapica. La radioterapia en el cáncer de recto puede hacer que la suspensión de quirófanos por el COVID-19 no merme las posibilidades de curación de los pacientes. 2020.[On line]
  47. Jones CM, Hawkins M, Mukherjee S, Radhakrishna G, Crosby T. Considerations for the Treatment of Oesophageal Cancer With Radiotherapy During the COVID-19 Pandemic. Clin Oncol (R Coll Radiol). 2020 Jun;32(6):354-357. | CrossRef | PubMed |
  48. Tchelebi LT, Haustermans K, Scorsetti M, Hosni A, Huguet F, Hawkins MA, et al. Recommendations for the use of radiation therapy in managing patients with gastrointestinal malignancies in the era of COVID-19. | CrossRef | PubMed |
  49. Alonzi R, Antoniou G, Anyamene N, Hoskin P, Hughes R, Ostler P, et al. Guidance for treatment of uro-oncology patients during COVID-19 pandemic. R. Coll. Radiol. 2020. [On line] | Link |
  50. Birtle A, Varughese M, Hoskin P, Choudhury A, James N, Huddart R. Guidance for management of urothelial cancer during COVID19 pandemic- radiotherapy. R. Coll. Radiol. 2020.[On line] | Link |
  51. American Brachytherapy Society. ABS Statement on Coronavirus. 2020. [On line] | Link |
  52. Ramirez PT, Chiva L, Eriksson AGZ, Frumovitz M, Fagotti A, Gonzalez Martin A, et al. COVID-19 Global Pandemic: Options for Management of Gynecologic Cancers. Int J Gynecol Cancer. 2020 May;30(5):561-563. | CrossRef | PubMed |
  53. Cooper AR, Taylor A. Proposed guidance for radiotherapy for gynaecological cancer and COVID-19. R. Coll. Radiol. 2020. | Link |
  54. Williams VM, Kahn JM, Harkenrider MM, Chino J, Chen J, Fang LC, et al. COVID-19 impact on timing of brachytherapy treatment and strategies for risk mitigation. Brachytherapy. 2020 Jul-Aug;19(4):401-411. | CrossRef | PubMed |
  55. Al-Rashdan A, Roumeliotis M, Quirk S, Grendarova P, Phan T, Cao J, et al. Adapting Radiation Therapy Treatments for Patients with Breast Cancer During the COVID-19 Pandemic: Hypo-Fractionation and Accelerated Partial Breast Irradiation to Address World Health Organization Recommendations. Adv Radiat Oncol. 2020 Apr 2;5(4):575–6. | CrossRef | PubMed |
  56. Braunstein LZ, Gillespie EF, Hong L, Xu A, Bakhoum SF, Cuaron J, et al. Breast Radiation Therapy Under COVID-19 Pandemic Resource Constraints-Approaches to Defer or Shorten Treatment From a Comprehensive Cancer Center in the United States. Adv Radiat Oncol. 2020 Apr 1;5(4):582-588. | CrossRef | PubMed |
  57. Coles CE, Aristei C, Bliss J, Boersma L, Brunt AM, Chatterjee S, et al. International Guidelines on Radiation Therapy for Breast Cancer During the COVID-19 Pandemic. Clin Oncol (R Coll Radiol). 2020 May;32(5):279-281. | CrossRef | PubMed |
  58. National Accreditation Program for Breast Cancer Centers. Recommendations for Prioritization, Treatment and Triage of Breast Cancer Patients During the COVID-19 Pandemic: Executive Summary. [On line] | Link |
  59. National Health Service - England. Clinical guide for the management of non-coronavirus patients requiring acute treatment : Cancer. 2020. [On line] | Link |
  60. Brunt M, Chakraborty S, Chatterjee S, Cleator S, Coles C, Kirby A, et al. Emergency guidelines for pre-operative breast radiotherapy during the COVID- 19 pandemic. 2020.[On line] | Link |
  61. Song AJ, Manukian G, Taylor AK, Anne PR, Simone NL. Concerns for Active Breathing Control (ABC) With Breast Cancer in the Era of COVID-19: Maximizing Infection Control While Minimizing Heart Dose. Adv Radiat Oncol. 2020 Apr 1;5(4):573-574. | CrossRef | PubMed |
  62. The Royal College of Radiologist. Neuro-oncology treatment guidance during COVID-19 pandemic. 2020.[On line] | Link |
  63. Yerramilli D, Xu AJ, Gillespie EF, Shepherd AF, Beal K, Gomez D, et al. Palliative Radiation Therapy for Oncologic Emergencies in the Setting of COVID-19: Approaches to Balancing Risks and Benefits. Adv Radiat Oncol. 2020 Apr 8;5(4):589-594. | CrossRef | PubMed |
  64. Haddad R, O'Neill A, Rabinowits G, Tishler R, Khuri F, Adkins D, et al. Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial. Lancet Oncol. 2013 Mar;14(3):257-64. | CrossRef | PubMed |
  65. Zhang B, Li MM, Chen WH, Zhao JF, Chen WQ, Dong YH, et al. Association of Chemoradiotherapy Regimens and Survival Among Patients With Nasopharyngeal Carcinoma: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019 Oct 2;2(10):e1913619. | CrossRef | PubMed |
  66. Rosenthal DI, Mohamed ASR, Garden AS, Morrison WH, El-Naggar AK, Kamal M, et al. Final Report of a Prospective Randomized Trial to Evaluate the Dose-Response Relationship for Postoperative Radiation Therapy and Pathologic Risk Groups in Patients With Head and Neck Cancer. Int J Radiat Oncol Biol Phys. 2017 Aug 1;98(5):1002-1011. | CrossRef | PubMed |
  67. Moon SH, Cho KH, Chung EJ, Lee CG, Lee KC, Chai GY, et al. A prospective randomized trial comparing hypofractionation with conventional fractionation radiotherapy for T1-2 glottic squamous cell carcinomas: results of a Korean Radiation Oncology Group (KROG-0201) study. Radiother Oncol. 2014 Jan;110(1):98-103. | CrossRef | PubMed |
  68. Sher DJ, Adelstein DJ, Bajaj GK, Brizel DM, Cohen EEW, Halthore A, et al. Radiation therapy for oropharyngeal squamous cell carcinoma: Executive summary of an ASTRO Evidence-Based Clinical Practice Guideline. Pract Radiat Oncol. 2017 Jul-Aug;7(4):246-253. | CrossRef | PubMed |
  69. Tobias JS, Monson K, Gupta N, Macdougall H, Glaholm J, Hutchison I, et al. Chemoradiotherapy for locally advanced head and neck cancer: 10-year follow-up of the UK Head and Neck (UKHAN1) trial. Lancet Oncol. 2010 Jan;11(1):66-74. | CrossRef | PubMed |
  70. Lacas B, Bourhis J, Overgaard J, Zhang Q, Grégoire V, Nankivell M, et al. Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta- analysis. Lancet Oncol. 2017 Sep;18(9):1221-1237. | CrossRef | PubMed |
  71. Zhou ZR, Liu SX, Zhang TS, Chen LX, Xia J, Hu ZD, et al. Short-course preoperative radiotherapy with immediate surgery versus long-course chemoradiation with delayed surgery in the treatment of rectal cancer: a systematic review and meta-analysis. Surg Oncol. 2014 Dec;23(4):211-21. | CrossRef | PubMed |
  72. Crosby T, Hurt CN, Falk S, Gollins S, Staffurth J, Ray R, et al. Long-term results and recurrence patterns from SCOPE-1: a phase II/III randomised trial of definitive chemoradiotherapy +/- cetuximab in oesophageal cancer. Br J Cancer. 2017 Mar 14;116(6):709-716. | CrossRef | PubMed |
  73. Jones CM, Spencer K, Hitchen C, Pelly T, Wood B, Hatfield P, et al. Hypofractionated Radiotherapy in Oesophageal Cancer for Patients Unfit for Systemic Therapy: A Retrospective Single-Centre Analysis. Clin Oncol (R Coll Radiol). 2019 Jun;31(6):356-364. | CrossRef | PubMed |
  74. Walsh TN, Noonan N, Hollywood D, Kelly A, Keeling N, Hennessy TP. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med. 1996 Aug 15;335(7):462-7. | CrossRef | PubMed |
  75. Deressa BT, Tigeneh W, Bogale N, Buwenge M, Morganti AG, Farina E. Short- Course 2 Dimensional Radiation Therapy in the Palliative Treatment of Esophageal Cancer in a Developing Country: A Phase II Study (Sharon Project). Int J Radiat Oncol Biol Phys. 2020 Jan 1;106(1):67-72. | CrossRef | PubMed |
  76. Shapiro J, van Lanschot JJB, Hulshof MCCM, van Hagen P, van Berge Henegouwen MI, Wijnhoven BPL, et al. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial. Lancet Oncol. 2015 Sep;16(9):1090-1098. | CrossRef | PubMed |
  77. Hamdy FC, Donovan JL, Lane JA, Mason M, Metcalfe C, Holding P, et al. 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer. N Engl J Med. 2016 Oct 13;375(15):1415-1424. | CrossRef | PubMed |
  78. Pisansky TM, Hunt D, Gomella LG, Amin MB, Balogh AG, Chinn DM, et al. Duration of androgen suppression before radiotherapy for localized prostate cancer: radiation therapy oncology group randomized clinical trial 9910. J Clin Oncol. 2015 Feb 1;33(4):332-9. | CrossRef | PubMed |
  79. Crook J, Ludgate C, Malone S, Perry G, Eapen L, Bowen J, et al. Final report of multicenter Canadian Phase III randomized trial of 3 versus 8 months of neoadjuvant androgen deprivation therapy before conventional- dose radiotherapy for clinically localized prostate cancer. Int J Radiat Oncol Biol Phys. 2009 Feb 1;73(2):327-33. | CrossRef | PubMed |
  80. Vale CL, Brihoum M, Chabaud S, Cook A, Fisher D, Forcat S, et al. Adjuvant or salvage radiotherapy for the treatment of localised prostate cancer? A prospectively planned aggregate data meta-analysis. Ann Oncol 2019;30:v883. | CrossRef |
  81. Parker CC, James ND, Brawley CD, Clarke NW, Hoyle AP, Ali A, et al. Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial. Lancet. 2018 Dec 1;392(10162):2353-2366. | CrossRef | PubMed |
  82. El-Monim HA, El-Baradie MM, Younis A, Ragab Y, Labib A, El-Attar I. A prospective randomized trial for postoperative vs. preoperative adjuvant radiotherapy for muscle-invasive bladder cancer. Urol Oncol. 2013 Apr;31(3):359-65. | CrossRef | PubMed |
  83. Morgan SC, Hoffman K, Loblaw DA, Buyyounouski MK, Patton C, Barocas D, et al. Hypofractionated Radiation Therapy for Localized Prostate Cancer: Executive Summary of an ASTRO, ASCO, and AUA Evidence-Based Guideline. Pract Radiat Oncol. 2018 Nov-Dec;8(6):354-360. | CrossRef | PubMed |
  84. Dearnaley D, Syndikus I, Mossop H, Khoo V, Birtle A, Bloomfield D, et al. Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial. Lancet Oncol. 2016 Aug;17(8):1047-1060. | CrossRef | PubMed |
  85. Porta N, Song YP, Hall E, Choudhury A, Owen R, Lewis R, et al. Hypo-Fractionation in Muscle-Invasive Bladder Cancer: An Individual Patient Data (IPD) Meta-Analysis of the BC2001 and BCON Trials. Int J Radiat Oncol 2019;105:S138. | CrossRef |
  86. ASTEC/EN.5 Study Group, Blake P, Swart AM, Orton J, Kitchener H, Whelan T, et al. Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis. Lancet. 2009 Jan 10;373(9658):137-46. | CrossRef | PubMed |
  87. Creutzberg CL, van Putten WL, Koper PC, Lybeert ML, Jobsen JJ, Wárlám-Rodenhuis CC, et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet. 2000 Apr 22;355(9213):1404-11. | CrossRef | PubMed |
  88. Chuang LT, Feldman S, Nakisige C, Temin S, Berek JS. Management and Care of Women With Invasive Cervical Cancer: ASCO Resource-Stratified Clinical Practice Guideline. J Clin Oncol. 2016 Sep 20;34(27):3354-5. | CrossRef | PubMed |
  89. Kokka F, Bryant A, Brockbank E, Powell M, Oram D. Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer. Cochrane Database Syst Rev. 2015 Apr 7;(4):CD010260. | CrossRef | PubMed |
  90. Albuquerque K, Hrycushko BA, Harkenrider MM, Mayadev J, Klopp A, Beriwal S, et al. Compendium of fractionation choices for gynecologic HDR brachytherapy-An American Brachytherapy Society Task Group Report. Brachytherapy. 2019 Jul-Aug;18(4):429-436. | CrossRef | PubMed |
  91. Morrow M, Van Zee KJ, Solin LJ, Houssami N, Chavez-MacGregor M, Harris JR, et al. Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast- Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma in Situ. Pract Radiat Oncol. 2016 Sep-Oct;6(5):287-295. | CrossRef | PubMed |
  92. Kunkler IH, Williams LJ, Jack WJ, Cameron DA, Dixon JM. Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial. Lancet Oncol. 2015 Mar;16(3):266-73. | CrossRef | PubMed |
  93. McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, et al. RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation. J Clin Oncol. 2015 Mar 1;33(7):709-15. | CrossRef | PubMed |
  94. Bartelink H, Maingon P, Poortmans P, Weltens C, Fourquet A, Jager J, et al. Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early cancer: 20-year follow-up of a randomised phase 3 trial. Lancet Oncol. 2015 Jan;16(1):47-56. | CrossRef | PubMed |
  95. Karlsson P, Cole BF, Colleoni M, Roncadin M, Chua BH, Murray E, et al. Timing of radiotherapy and outcome in patients receiving adjuvant endocrine therapy. Int J Radiat Oncol Biol Phys. 2011 Jun 1;80(2):398-402. | CrossRef | PubMed |
  96. Smith BD, Bellon JR, Blitzblau R, Freedman G, Haffty B, Hahn C, et al. Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline. Pract Radiat Oncol. 2018 May-Jun;8(3):145-152. | CrossRef | PubMed |
  97. Wang SL, Fang H, Song YW, Wang WH, Hu C, Liu YP, et al. Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer: a randomised, non- inferiority, open-label, phase 3 trial. Lancet Oncol. 2019 Mar;20(3):352-360. | CrossRef | PubMed |
  98. Correa C, Harris EE, Leonardi MC, Smith BD, Taghian AG, Thompson AM, et al. Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement. Pract Radiat Oncol. 2017 Mar-Apr;7(2):73-79. | CrossRef | PubMed |
  99. Yamaguchi M, Tobinai K, Oguchi M, Ishizuka N, Kobayashi Y, Isobe Y, et al. Concurrent chemoradiotherapy for localized nasal natural killer/T-cell lymphoma: an updated analysis of the Japan clinical oncology group study JCOG0211. J Clin Oncol. 2012 Nov 10;30(32):4044-6. | CrossRef | PubMed |
  100. Lowry L, Smith P, Qian W, Falk S, Benstead K, Illidge T, et al. Reduced dose radiotherapy for local control in non-Hodgkin lymphoma: a randomised phase III trial. Radiother Oncol. 2011 Jul;100(1):86-92. | CrossRef | PubMed |
  101. Hoskin PJ, Kirkwood AA, Popova B, Smith P, Robinson M, Gallop-Evans E, et al. 4 Gy versus 24 Gy radiotherapy for patients with indolent lymphoma (FORT): a randomised phase 3 non-inferiority trial. Lancet Oncol. 2014 Apr;15(4):457-63. | CrossRef | PubMed |
  102. Haas RL, Poortmans P, de Jong D, Aleman BM, Dewit LG, Verheij M, et al. High response rates and lasting remissions after low-dose involved field radiotherapy in indolent lymphomas. J Clin Oncol. 2003 Jul 1;21(13):2474-80. | CrossRef | PubMed |
  103. Wick W, Platten M, Meisner C, Felsberg J, Tabatabai G, Simon M, et al. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol. 2012 Jul;13(7):707-15. | CrossRef | PubMed |
  104. Cairncross G, Wang M, Shaw E, Jenkins R, Brachman D, Buckner J, et al. Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402. J Clin Oncol. 2013 Jan 20;31(3):337-43. | CrossRef | PubMed |
  105. Van den Bent MJ, Afra D, de Witte O, Ben Hassel M, Schraub S, Hoang-Xuan K, et al. Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial. Lancet. 2005 Sep 17 23;366(9490):985-90. | CrossRef | PubMed |
  106. Hanna C, Lawrie TA, Rogozińska E, Kernohan A, Jefferies S, Bulbeck H, et al. Treatment of newly diagnosed glioblastoma in the elderly: a network meta-analysis. Cochrane Database Syst Rev. 2020 Mar 23;3(3):CD013261. | CrossRef | PubMed |
  107. Guedes de Castro D, Matiello J, Roa W, Ghosh S, Kepka L, Kumar N, et al. Survival Outcomes With Short- Course Radiation Therapy in Elderly Patients With Glioblastoma: Data From a Randomized Phase 3 Trial. Int J Radiat Oncol Biol Phys. 2017 Jul 15;98(4):931-938. | CrossRef | PubMed |
  108. Likhacheva A, Awan M, Barker CA, Bhatnagar A, Bradfield L, Brady MS, et al. Definitive and Postoperative Radiation Therapy for Basal and Squamous Cell Cancers of the Skin: Executive Summary of an American Society for Radiation Oncology Clinical Practice Guideline. Pract Radiat Oncol. 2020 Jan-Feb;10(1):8-20. | CrossRef | PubMed |
  109. Yu JB, Wilson LD, Detterbeck FC. Superior vena cava syndrome--a proposed classification system and algorithm for management. J Thorac Oncol. 2008 Aug;3(8):811-4. | CrossRef | PubMed |
  110. Tsao MN, Xu W, Wong RK, Lloyd N, Laperriere N, Sahgal A, et al. Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases. Cochrane Database Syst Rev. 2018 Jan 25;1(1):CD003869. | CrossRef | PubMed |
  111. Lutz S, Balboni T, Jones J, Lo S, Petit J, Rich SE, et al. Palliative radiation therapy for bone metastases: Update of an ASTRO Evidence- Based Guideline. Pract Radiat Oncol. 2017 Jan Feb;7(1):4-12. | CrossRef | PubMed |
  112. Rich SE, Chow R, Raman S, Liang Zeng K, Lutz S, Lam H, et al. Update of the systematic review of palliative radiation therapy fractionation for bone metastases. Radiother Oncol. 2018 Mar;126(3):547-557. | CrossRef | PubMed |
  113. Sundstrøm S, Bremnes R, Aasebø U, Aamdal S, Hatlevoll R, Brunsvig P, et al. Hypofractionated palliative radiotherapy (17 Gy per two fractions) in advanced non-small-cell lung carcinoma is comparable to standard fractionation for symptom control and survival: a national phase III trial. J Clin Oncol. 2004 Mar 1;22(5):801-10. | CrossRef | PubMed |
World Health Organization. Coronavirus disease. Situation Report 166.2020. [On line] | Link |

Muñoz N. COVID-19 in Latin America: a first glance to the mortality. Colomb Med. 2020; 51(2). | CrossRef |

El-Shakankery KH, Kefas J, Crusz SM. Caring for our cancer patients in the wake of COVID-19. Br J Cancer. 2020 Jul;123(1):3-4. | CrossRef | PubMed |

Liang W, Guan W, Chen R, Wang W, Li J, Xu K, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020 Mar;21(3):335-337. | CrossRef | PubMed |

Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak. Cancer Discov. 2020 Jun;10(6):783-791. | CrossRef | PubMed |

Yap ML, Hanna TP, Shafiq J, Ferlay J, Bray F, Delaney GP, et al. The Benefits of Providing External Beam Radiotherapy in Low- and Middle-income Countries. Clin Oncol (R Coll Radiol). 2017 Feb;29(2):72-83. | CrossRef | PubMed |

Zaorsky NG, Yu JB, McBride SM, Dess RT, Jackson WC, Mahal BA, et al. Prostate Cancer Radiation Therapy Recommendations in Response to COVID-19. Adv Radiat Oncol. 2020 Apr 1;5(4):659-665. | CrossRef | PubMed |

Varker T, Forbes D, Dell L, Weston A, Merlin T, Hodson S, et al. Rapid evidence assessment: increasing the transparency of an emerging methodology. J Eval Clin Pract. 2015 Dec;21(6):1199-204. | CrossRef | PubMed |

Loblaw DA, Prestrud AA, Somerfield MR, Oliver TK, Brouwers MC, Nam RK, et al. American Society of Clinical Oncology Clinical Practice Guidelines: formal systematic review-based consensus methodology. J Clin Oncol. 2012 Sep 1;30(25):3136-40. | CrossRef | PubMed |

The Royal College of Radiologist. PRINCIPLES FOR RADIATION THERAPY SERVICES DURING COVID19. [On line] | Link |

Achard V, Tsoutsou P, Zilli T. Radiotherapy in the time of the Coronavirus pandemic: when less is better. Int J Radiat Oncol Biol Phys. 2020 Jul 1;107(3):600-601.

Provincial Health Services Authority. Provincial Cancer Clinical Management Guidelines in Pandemic Situation ( COVID-19 ). 2020. [On line] | Link |

Chen W, Su XY, Wang VJ, Wang EC, Xu R, Zhong S, et al. Novel Coronavirus International Public Health Emergency: Guidance on Radiation Oncology Facility Operation. Adv Radiat Oncol. 2020 Apr 1;5(4):560-566. | CrossRef | PubMed |

Chen YL, Hsu FM, Tsai CJ, Cheng JC. Efforts to Reduce the Impact of Coronavirus Disease 2019 Outbreak on Radiation Oncology in Taiwan. Adv Radiat Oncol. 2020 Apr 6;5(4):534-537. | CrossRef | PubMed |

Dinh TT, Halasz LM, Ford E, Rengan R. Radiation Therapy in King County, Washington During the COVID-19 Pandemic: Balancing Patient Care, TransmissionMitigation, and Resident Training. Adv Radiat Oncol. 2020 Mar 27;5(4):544-547. | CrossRef | PubMed |

Filippi AR, Russi E, Magrini SM, Corvò R. Letter from Italy: First practical indications for radiation therapy departments during COVID-19 outbreak. Int J Radiat Oncol Biol Phys. 2020 Jul 1;107(3):597-599. | CrossRef | PubMed |

Krengli M, Ferrara E, Mastroleo F, Brambilla M, Ricardi U. Running a Radiation Oncology Department at the Time of Coronavirus: An Italian Experience. Adv Radiat Oncol. 2020 Mar 20;5(4):527-530. | CrossRef | PubMed |

Sociedad Española de Oncología Médica, Sociedad Española de Oncología Radioterápica. Documento técnico Recomendaciones para el manejo , prevención y control de COVID-19 en los hospitales de día onco-hematológicos y servicios de oncología radioterápica. 2020. [On line] | Link |

Mukherjee RK, Back MF, Lu JJ, Shakespeare TP, Wynne CJ. Hiding in the bunker: Challenges for a radiation oncology department operating in the Severe Acute Respiratory Syndrome outbreak. Australas Radiol. 2003 Jun;47(2):143-5. | CrossRef | PubMed |

National Institute for Health and Care Excellence. COVID-19 rapid guideline: delivery of radiotherapy. 2020;1–15.[On line] | Link |

Papachristofilou A, Finazzi T, Kohler G, Dott C, Zimmermann F. Contingency Plans in a Radiation Oncology Department Amid the 2019-nCoV Outbreak in Switzerland. Adv Radiat Oncol. 2020 Mar 31;5(4):577-581. | CrossRef | PubMed |

Peter MacCallum Cancer Centre. COVID-19 Clinical Services Response Plan - DRO - March 2020 V3. 2020.[On line] | Link |

Rao YJ, Provenzano D, Gay HA, Read PW, Ojong M, Goyal S. A Radiation Oncology Departmental Policy for the 2019 Novel Coronavirus (COVID-19) Pandemic. Preprints 2020:1–17. | CrossRef |

Rivera A, Ohri N, Thomas E, Miller R, Knoll MA. The Impact of COVID-19 on Radiation Oncology Clinics and Patients With Cancer in the United States. Adv Radiat Oncol. 2020 Mar 27;5(4):538-543. | CrossRef | PubMed |

Sociedad Española de Oncología Radioterapica. Recomendaciones Generales ante la situación de pandemia por COVID-19 en el área de Oncología Radioterápica. 2020.[On line] | Link |

Simcock R, Thomas TV, Estes C, Filippi AR, Katz MA, Pereira IJ, et al. COVID-19: Global radiation oncology's targeted response for pandemic preparedness. Clin Transl Radiat Oncol. 2020 Mar 24;22:55-68. | CrossRef | PubMed |

Wright JL, Alcorn SR, McNutt T, Han-Oh S, Gonzalez R, Lin L, et al. An Integrated Program in a Pandemic: Johns Hopkins Radiation Oncology Department. Adv Radiat Oncol. 2020 Apr 9;5(4):666-672. | CrossRef | PubMed |

Wu S, Zheng D, Liu Y, Hu D, Wei W, Han G. Radiation Therapy Care During a Major Outbreak of COVID-19 in Wuhan. Adv Radiat Oncol. 2020 Mar 27;5(4):531-533. | CrossRef | PubMed |

Mascarin M, Coassin E, Provenzi M, Franchin G, Mariotto A. How to Reorganize Children's Access to Radiation Therapy in the Era of COVID-19, to Protect Them and Elderly Patients. Adv Radiat Oncol. 2020 Apr 11;5(4):673-674. | CrossRef | PubMed |

Lu JJ. Experience of a Radiation Oncology Center Operating During the COVID-19 Outbreak. Adv Radiat Oncol. 2020 Apr 10;5(4):548-549. | CrossRef | PubMed |

Samiee S, Hadjilooei F, Alamolhoda M, Akhlaghpoor S. New Policy and Regulations for a Radiology-Oncology Center During the COVID-19 Outbreak in Tehran, Iran. Adv Radiat Oncol. 2020 Apr 14;5(4):550-557. | CrossRef | PubMed |

Wei W, Zheng D, Lei Y, Wu S, Verma V, Liu Y, et al. Radiotherapy workflow and protection procedures during the Coronavirus Disease 2019 (COVID-19) outbreak: Experience of the Hubei Cancer Hospital in Wuhan, China. Radiother Oncol. 2020 Jul;148:203-210. | CrossRef | PubMed |

Wei W, Jiang H, Chen W, Zhou Y, Guo S, Zhong G, et al. How should we implement radiotherapy for cancer patients in China during the endemic period of COVID-19? Radiother Oncol. 2020 Jun;147:100-102. | CrossRef | PubMed |

Tey J, Ho S, Choo BA, Ho F, Yap SP, Tuan JKL, et al. Navigating the challenges of the COVID-19 outbreak: Perspectives from the radiation oncology service in Singapore. Radiother Oncol. 2020 Jul;148:189-193. | CrossRef | PubMed |

De Felice F, Polimeni A, Tombolini V. The impact of Coronavirus (COVID-19) on head and neck cancer patients' care. Radiother Oncol. 2020 Jun;147:84-85. | CrossRef | PubMed |

Gay HA, Santiago R, Gil B, Remedios C, Montes PJ, López-Araujo J, et al. Lessons Learned From Hurricane Maria in Puerto Rico: Practical Measures to Mitigate the Impact of a Catastrophic Natural Disaster on Radiation Oncology Patients. Pract Radiat Oncol. 2019 Sep-Oct;9(5):305-321. | CrossRef | PubMed |

Roques T, Prestwich R. Head and neck cancer and COVID-19. The Royal College of Radiologist. 2020. [On line] | Link |

Yale School of Medicine Department of Therapeutic Radiology faculty. COVID19 Yale Radiation Oncology Flowchart –. 2020. | Link |

Thomson DJ, Palma D, Guckenberger M, Balermpas P, Beitler JJ, Blanchard P, et al. Practice Recommendations for Risk- Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic: An ASTRO-ESTRO Consensus Statement. Int J Radiat Oncol Biol Phys. 2020 Jul 15;107(4):618-627 | CrossRef | PubMed |

De Felice F, Petrucciani N. Treatment approach in locally advanced rectal cancer during coronavirus (COVID-19) pandemic: long course or short course? Colorectal Dis. 2020 Jun;22(6):642-643. | CrossRef | PubMed |

Marijnen CAM, Peters FP, Rödel C, Bujko K, Haustermans K, Fokas E, et al. International expert consensus statement regarding radiotherapy treatment options for rectal cancer during the COVID 19 pandemic. Radiother Oncol. 2020 Jul;148:213-215. | CrossRef | PubMed |

Oxford Colorrectal Oncologists. Lower GI response to Covid-19 outbreak. 2020;:1–2.[On line] | Link |

Grose D, Hunt A, Katharine Aitken, Mukherjee S, Hawkins M, Radhakrishna G, et al. RADIOTHERAPY PROTOCOL : Radical Pancreas 15 fraction ( adapted from PRIMUS 002 radiotherapy protocol and RMH research protocol ). The Royal College of Radiologists. 2020. [On line] | Link |

Mukjerjee S, Hawkins M, Aitkin K, Radhakrishna G, Gose D, Godoy R, et al. Hypofractionated Radical Pancreas (5 fraction) (adapted from Oxford Protocol and SPARC trial). 2020. [On line] | Link |

Mukherjee S, Jones C. Considerations for treatment of pancreatic cancer within the United Kingdom during the COVID-19 pandemic.[On line] | Link |

Sociedad Española de Oncología Radioterapica. La radioterapia en el cáncer de recto puede hacer que la suspensión de quirófanos por el COVID-19 no merme las posibilidades de curación de los pacientes. 2020.[On line]

Jones CM, Hawkins M, Mukherjee S, Radhakrishna G, Crosby T. Considerations for the Treatment of Oesophageal Cancer With Radiotherapy During the COVID-19 Pandemic. Clin Oncol (R Coll Radiol). 2020 Jun;32(6):354-357. | CrossRef | PubMed |

Tchelebi LT, Haustermans K, Scorsetti M, Hosni A, Huguet F, Hawkins MA, et al. Recommendations for the use of radiation therapy in managing patients with gastrointestinal malignancies in the era of COVID-19. | CrossRef | PubMed |

Alonzi R, Antoniou G, Anyamene N, Hoskin P, Hughes R, Ostler P, et al. Guidance for treatment of uro-oncology patients during COVID-19 pandemic. R. Coll. Radiol. 2020. [On line] | Link |

Birtle A, Varughese M, Hoskin P, Choudhury A, James N, Huddart R. Guidance for management of urothelial cancer during COVID19 pandemic- radiotherapy. R. Coll. Radiol. 2020.[On line] | Link |

American Brachytherapy Society. ABS Statement on Coronavirus. 2020. [On line] | Link |

Ramirez PT, Chiva L, Eriksson AGZ, Frumovitz M, Fagotti A, Gonzalez Martin A, et al. COVID-19 Global Pandemic: Options for Management of Gynecologic Cancers. Int J Gynecol Cancer. 2020 May;30(5):561-563. | CrossRef | PubMed |

Cooper AR, Taylor A. Proposed guidance for radiotherapy for gynaecological cancer and COVID-19. R. Coll. Radiol. 2020. | Link |

Williams VM, Kahn JM, Harkenrider MM, Chino J, Chen J, Fang LC, et al. COVID-19 impact on timing of brachytherapy treatment and strategies for risk mitigation. Brachytherapy. 2020 Jul-Aug;19(4):401-411. | CrossRef | PubMed |

Al-Rashdan A, Roumeliotis M, Quirk S, Grendarova P, Phan T, Cao J, et al. Adapting Radiation Therapy Treatments for Patients with Breast Cancer During the COVID-19 Pandemic: Hypo-Fractionation and Accelerated Partial Breast Irradiation to Address World Health Organization Recommendations. Adv Radiat Oncol. 2020 Apr 2;5(4):575–6. | CrossRef | PubMed |

Braunstein LZ, Gillespie EF, Hong L, Xu A, Bakhoum SF, Cuaron J, et al. Breast Radiation Therapy Under COVID-19 Pandemic Resource Constraints-Approaches to Defer or Shorten Treatment From a Comprehensive Cancer Center in the United States. Adv Radiat Oncol. 2020 Apr 1;5(4):582-588. | CrossRef | PubMed |

Coles CE, Aristei C, Bliss J, Boersma L, Brunt AM, Chatterjee S, et al. International Guidelines on Radiation Therapy for Breast Cancer During the COVID-19 Pandemic. Clin Oncol (R Coll Radiol). 2020 May;32(5):279-281. | CrossRef | PubMed |

National Accreditation Program for Breast Cancer Centers. Recommendations for Prioritization, Treatment and Triage of Breast Cancer Patients During the COVID-19 Pandemic: Executive Summary. [On line] | Link |

National Health Service - England. Clinical guide for the management of non-coronavirus patients requiring acute treatment : Cancer. 2020. [On line] | Link |

Brunt M, Chakraborty S, Chatterjee S, Cleator S, Coles C, Kirby A, et al. Emergency guidelines for pre-operative breast radiotherapy during the COVID- 19 pandemic. 2020.[On line] | Link |

Song AJ, Manukian G, Taylor AK, Anne PR, Simone NL. Concerns for Active Breathing Control (ABC) With Breast Cancer in the Era of COVID-19: Maximizing Infection Control While Minimizing Heart Dose. Adv Radiat Oncol. 2020 Apr 1;5(4):573-574. | CrossRef | PubMed |

The Royal College of Radiologist. Neuro-oncology treatment guidance during COVID-19 pandemic. 2020.[On line] | Link |

Yerramilli D, Xu AJ, Gillespie EF, Shepherd AF, Beal K, Gomez D, et al. Palliative Radiation Therapy for Oncologic Emergencies in the Setting of COVID-19: Approaches to Balancing Risks and Benefits. Adv Radiat Oncol. 2020 Apr 8;5(4):589-594. | CrossRef | PubMed |

Haddad R, O'Neill A, Rabinowits G, Tishler R, Khuri F, Adkins D, et al. Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial. Lancet Oncol. 2013 Mar;14(3):257-64. | CrossRef | PubMed |

Zhang B, Li MM, Chen WH, Zhao JF, Chen WQ, Dong YH, et al. Association of Chemoradiotherapy Regimens and Survival Among Patients With Nasopharyngeal Carcinoma: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019 Oct 2;2(10):e1913619. | CrossRef | PubMed |

Rosenthal DI, Mohamed ASR, Garden AS, Morrison WH, El-Naggar AK, Kamal M, et al. Final Report of a Prospective Randomized Trial to Evaluate the Dose-Response Relationship for Postoperative Radiation Therapy and Pathologic Risk Groups in Patients With Head and Neck Cancer. Int J Radiat Oncol Biol Phys. 2017 Aug 1;98(5):1002-1011. | CrossRef | PubMed |

Moon SH, Cho KH, Chung EJ, Lee CG, Lee KC, Chai GY, et al. A prospective randomized trial comparing hypofractionation with conventional fractionation radiotherapy for T1-2 glottic squamous cell carcinomas: results of a Korean Radiation Oncology Group (KROG-0201) study. Radiother Oncol. 2014 Jan;110(1):98-103. | CrossRef | PubMed |

Sher DJ, Adelstein DJ, Bajaj GK, Brizel DM, Cohen EEW, Halthore A, et al. Radiation therapy for oropharyngeal squamous cell carcinoma: Executive summary of an ASTRO Evidence-Based Clinical Practice Guideline. Pract Radiat Oncol. 2017 Jul-Aug;7(4):246-253. | CrossRef | PubMed |

Tobias JS, Monson K, Gupta N, Macdougall H, Glaholm J, Hutchison I, et al. Chemoradiotherapy for locally advanced head and neck cancer: 10-year follow-up of the UK Head and Neck (UKHAN1) trial. Lancet Oncol. 2010 Jan;11(1):66-74. | CrossRef | PubMed |

Lacas B, Bourhis J, Overgaard J, Zhang Q, Grégoire V, Nankivell M, et al. Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta- analysis. Lancet Oncol. 2017 Sep;18(9):1221-1237. | CrossRef | PubMed |

Zhou ZR, Liu SX, Zhang TS, Chen LX, Xia J, Hu ZD, et al. Short-course preoperative radiotherapy with immediate surgery versus long-course chemoradiation with delayed surgery in the treatment of rectal cancer: a systematic review and meta-analysis. Surg Oncol. 2014 Dec;23(4):211-21. | CrossRef | PubMed |

Crosby T, Hurt CN, Falk S, Gollins S, Staffurth J, Ray R, et al. Long-term results and recurrence patterns from SCOPE-1: a phase II/III randomised trial of definitive chemoradiotherapy +/- cetuximab in oesophageal cancer. Br J Cancer. 2017 Mar 14;116(6):709-716. | CrossRef | PubMed |

Jones CM, Spencer K, Hitchen C, Pelly T, Wood B, Hatfield P, et al. Hypofractionated Radiotherapy in Oesophageal Cancer for Patients Unfit for Systemic Therapy: A Retrospective Single-Centre Analysis. Clin Oncol (R Coll Radiol). 2019 Jun;31(6):356-364. | CrossRef | PubMed |

Walsh TN, Noonan N, Hollywood D, Kelly A, Keeling N, Hennessy TP. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med. 1996 Aug 15;335(7):462-7. | CrossRef | PubMed |

Deressa BT, Tigeneh W, Bogale N, Buwenge M, Morganti AG, Farina E. Short- Course 2 Dimensional Radiation Therapy in the Palliative Treatment of Esophageal Cancer in a Developing Country: A Phase II Study (Sharon Project). Int J Radiat Oncol Biol Phys. 2020 Jan 1;106(1):67-72. | CrossRef | PubMed |

Shapiro J, van Lanschot JJB, Hulshof MCCM, van Hagen P, van Berge Henegouwen MI, Wijnhoven BPL, et al. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial. Lancet Oncol. 2015 Sep;16(9):1090-1098. | CrossRef | PubMed |

Hamdy FC, Donovan JL, Lane JA, Mason M, Metcalfe C, Holding P, et al. 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer. N Engl J Med. 2016 Oct 13;375(15):1415-1424. | CrossRef | PubMed |

Pisansky TM, Hunt D, Gomella LG, Amin MB, Balogh AG, Chinn DM, et al. Duration of androgen suppression before radiotherapy for localized prostate cancer: radiation therapy oncology group randomized clinical trial 9910. J Clin Oncol. 2015 Feb 1;33(4):332-9. | CrossRef | PubMed |

Crook J, Ludgate C, Malone S, Perry G, Eapen L, Bowen J, et al. Final report of multicenter Canadian Phase III randomized trial of 3 versus 8 months of neoadjuvant androgen deprivation therapy before conventional- dose radiotherapy for clinically localized prostate cancer. Int J Radiat Oncol Biol Phys. 2009 Feb 1;73(2):327-33. | CrossRef | PubMed |

Vale CL, Brihoum M, Chabaud S, Cook A, Fisher D, Forcat S, et al. Adjuvant or salvage radiotherapy for the treatment of localised prostate cancer? A prospectively planned aggregate data meta-analysis. Ann Oncol 2019;30:v883. | CrossRef |

Parker CC, James ND, Brawley CD, Clarke NW, Hoyle AP, Ali A, et al. Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial. Lancet. 2018 Dec 1;392(10162):2353-2366. | CrossRef | PubMed |

El-Monim HA, El-Baradie MM, Younis A, Ragab Y, Labib A, El-Attar I. A prospective randomized trial for postoperative vs. preoperative adjuvant radiotherapy for muscle-invasive bladder cancer. Urol Oncol. 2013 Apr;31(3):359-65. | CrossRef | PubMed |

Morgan SC, Hoffman K, Loblaw DA, Buyyounouski MK, Patton C, Barocas D, et al. Hypofractionated Radiation Therapy for Localized Prostate Cancer: Executive Summary of an ASTRO, ASCO, and AUA Evidence-Based Guideline. Pract Radiat Oncol. 2018 Nov-Dec;8(6):354-360. | CrossRef | PubMed |

Dearnaley D, Syndikus I, Mossop H, Khoo V, Birtle A, Bloomfield D, et al. Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial. Lancet Oncol. 2016 Aug;17(8):1047-1060. | CrossRef | PubMed |

Porta N, Song YP, Hall E, Choudhury A, Owen R, Lewis R, et al. Hypo-Fractionation in Muscle-Invasive Bladder Cancer: An Individual Patient Data (IPD) Meta-Analysis of the BC2001 and BCON Trials. Int J Radiat Oncol 2019;105:S138. | CrossRef |

ASTEC/EN.5 Study Group, Blake P, Swart AM, Orton J, Kitchener H, Whelan T, et al. Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis. Lancet. 2009 Jan 10;373(9658):137-46. | CrossRef | PubMed |

Creutzberg CL, van Putten WL, Koper PC, Lybeert ML, Jobsen JJ, Wárlám-Rodenhuis CC, et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet. 2000 Apr 22;355(9213):1404-11. | CrossRef | PubMed |

Chuang LT, Feldman S, Nakisige C, Temin S, Berek JS. Management and Care of Women With Invasive Cervical Cancer: ASCO Resource-Stratified Clinical Practice Guideline. J Clin Oncol. 2016 Sep 20;34(27):3354-5. | CrossRef | PubMed |

Kokka F, Bryant A, Brockbank E, Powell M, Oram D. Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer. Cochrane Database Syst Rev. 2015 Apr 7;(4):CD010260. | CrossRef | PubMed |

Albuquerque K, Hrycushko BA, Harkenrider MM, Mayadev J, Klopp A, Beriwal S, et al. Compendium of fractionation choices for gynecologic HDR brachytherapy-An American Brachytherapy Society Task Group Report. Brachytherapy. 2019 Jul-Aug;18(4):429-436. | CrossRef | PubMed |

Morrow M, Van Zee KJ, Solin LJ, Houssami N, Chavez-MacGregor M, Harris JR, et al. Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast- Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma in Situ. Pract Radiat Oncol. 2016 Sep-Oct;6(5):287-295. | CrossRef | PubMed |

Kunkler IH, Williams LJ, Jack WJ, Cameron DA, Dixon JM. Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial. Lancet Oncol. 2015 Mar;16(3):266-73. | CrossRef | PubMed |

McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, et al. RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation. J Clin Oncol. 2015 Mar 1;33(7):709-15. | CrossRef | PubMed |

Bartelink H, Maingon P, Poortmans P, Weltens C, Fourquet A, Jager J, et al. Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early cancer: 20-year follow-up of a randomised phase 3 trial. Lancet Oncol. 2015 Jan;16(1):47-56. | CrossRef | PubMed |

Karlsson P, Cole BF, Colleoni M, Roncadin M, Chua BH, Murray E, et al. Timing of radiotherapy and outcome in patients receiving adjuvant endocrine therapy. Int J Radiat Oncol Biol Phys. 2011 Jun 1;80(2):398-402. | CrossRef | PubMed |

Smith BD, Bellon JR, Blitzblau R, Freedman G, Haffty B, Hahn C, et al. Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline. Pract Radiat Oncol. 2018 May-Jun;8(3):145-152. | CrossRef | PubMed |

Wang SL, Fang H, Song YW, Wang WH, Hu C, Liu YP, et al. Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer: a randomised, non- inferiority, open-label, phase 3 trial. Lancet Oncol. 2019 Mar;20(3):352-360. | CrossRef | PubMed |

Correa C, Harris EE, Leonardi MC, Smith BD, Taghian AG, Thompson AM, et al. Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement. Pract Radiat Oncol. 2017 Mar-Apr;7(2):73-79. | CrossRef | PubMed |

Yamaguchi M, Tobinai K, Oguchi M, Ishizuka N, Kobayashi Y, Isobe Y, et al. Concurrent chemoradiotherapy for localized nasal natural killer/T-cell lymphoma: an updated analysis of the Japan clinical oncology group study JCOG0211. J Clin Oncol. 2012 Nov 10;30(32):4044-6. | CrossRef | PubMed |

Lowry L, Smith P, Qian W, Falk S, Benstead K, Illidge T, et al. Reduced dose radiotherapy for local control in non-Hodgkin lymphoma: a randomised phase III trial. Radiother Oncol. 2011 Jul;100(1):86-92. | CrossRef | PubMed |

Hoskin PJ, Kirkwood AA, Popova B, Smith P, Robinson M, Gallop-Evans E, et al. 4 Gy versus 24 Gy radiotherapy for patients with indolent lymphoma (FORT): a randomised phase 3 non-inferiority trial. Lancet Oncol. 2014 Apr;15(4):457-63. | CrossRef | PubMed |

Haas RL, Poortmans P, de Jong D, Aleman BM, Dewit LG, Verheij M, et al. High response rates and lasting remissions after low-dose involved field radiotherapy in indolent lymphomas. J Clin Oncol. 2003 Jul 1;21(13):2474-80. | CrossRef | PubMed |

Wick W, Platten M, Meisner C, Felsberg J, Tabatabai G, Simon M, et al. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol. 2012 Jul;13(7):707-15. | CrossRef | PubMed |

Cairncross G, Wang M, Shaw E, Jenkins R, Brachman D, Buckner J, et al. Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402. J Clin Oncol. 2013 Jan 20;31(3):337-43. | CrossRef | PubMed |

Van den Bent MJ, Afra D, de Witte O, Ben Hassel M, Schraub S, Hoang-Xuan K, et al. Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial. Lancet. 2005 Sep 17 23;366(9490):985-90. | CrossRef | PubMed |

Hanna C, Lawrie TA, Rogozińska E, Kernohan A, Jefferies S, Bulbeck H, et al. Treatment of newly diagnosed glioblastoma in the elderly: a network meta-analysis. Cochrane Database Syst Rev. 2020 Mar 23;3(3):CD013261. | CrossRef | PubMed |

Guedes de Castro D, Matiello J, Roa W, Ghosh S, Kepka L, Kumar N, et al. Survival Outcomes With Short- Course Radiation Therapy in Elderly Patients With Glioblastoma: Data From a Randomized Phase 3 Trial. Int J Radiat Oncol Biol Phys. 2017 Jul 15;98(4):931-938. | CrossRef | PubMed |

Likhacheva A, Awan M, Barker CA, Bhatnagar A, Bradfield L, Brady MS, et al. Definitive and Postoperative Radiation Therapy for Basal and Squamous Cell Cancers of the Skin: Executive Summary of an American Society for Radiation Oncology Clinical Practice Guideline. Pract Radiat Oncol. 2020 Jan-Feb;10(1):8-20. | CrossRef | PubMed |

Yu JB, Wilson LD, Detterbeck FC. Superior vena cava syndrome--a proposed classification system and algorithm for management. J Thorac Oncol. 2008 Aug;3(8):811-4. | CrossRef | PubMed |

Tsao MN, Xu W, Wong RK, Lloyd N, Laperriere N, Sahgal A, et al. Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases. Cochrane Database Syst Rev. 2018 Jan 25;1(1):CD003869. | CrossRef | PubMed |

Lutz S, Balboni T, Jones J, Lo S, Petit J, Rich SE, et al. Palliative radiation therapy for bone metastases: Update of an ASTRO Evidence- Based Guideline. Pract Radiat Oncol. 2017 Jan Feb;7(1):4-12. | CrossRef | PubMed |

Rich SE, Chow R, Raman S, Liang Zeng K, Lutz S, Lam H, et al. Update of the systematic review of palliative radiation therapy fractionation for bone metastases. Radiother Oncol. 2018 Mar;126(3):547-557. | CrossRef | PubMed |

Sundstrøm S, Bremnes R, Aasebø U, Aamdal S, Hatlevoll R, Brunsvig P, et al. Hypofractionated palliative radiotherapy (17 Gy per two fractions) in advanced non-small-cell lung carcinoma is comparable to standard fractionation for symptom control and survival: a national phase III trial. J Clin Oncol. 2004 Mar 1;22(5):801-10. | CrossRef | PubMed |